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UnknownThe Crucial Role of Noncovalent Interactions in PLGA Nanoparticles: Impact on Carvacrol/<i>p</i>‑Cymene Release, Biological Activity, and Antibiofilm Properties.
Understanding the molecular interactions between polymeric carriers and bioactive compounds is critical for designing advanced drug delivery systems. This study focuses on two nanoparticle systems composed of poly-(lactic-co-glycolic acid) (PLGA) encapsulating either carvacrol or p-cym...
S-EPMC12809508 | biostudies-literature
UnknownDevelopment and Internal Validation of a Predictive Model for Operative Management in Blunt Abdominal Trauma Using Admission Physiological and Biochemical Parameters.
Background: Early identification of patients requiring operative management (OM) after blunt abdominal trauma is critical, yet initial physiological signs may be nonspecific. We sought to develop and internally validate an admission-based prediction model for early emergency department (ED) t...
S-EPMC12693253 | biostudies-literature
UnknownSpanish Pediatric Inflammatory Bowel Disease Diagnostic Delay Registry: SPIDER Study From Sociedad Espanola de Gastroenterologia, Hepatologia y Nutricion Pediatrica.
Background and Aims: Diagnostic delay (DD) is especially relevant in children with inflammatory bowel disease, leading to potential complications. We examined the intervals and factors for DD in the pediatric population of Spain. Methods: We conducted a multicentric prospective study, ...
S-EPMC7593447 | biostudies-literature
UnknownImpact of Biological Agents on Postsurgical Complications in Inflammatory Bowel Disease: A Multicentre Study of Geteccu.

Background

The impact of biologics on the risk of postoperative complications (PC) in inflammatory bowel disease (IBD) is still an ongoing debate. This lack of evidence is more relevant for ustekinumab and vedolizumab.

Aims

To evaluate the impact of biologics on the risk of PC.

Met...

S-EPMC8509475 | biostudies-literature
UnknownImpact of neuromuscular block monitoring and reversal on postoperative pulmonary complications in thoracic surgery: a Bayesian analysis of the iPROVE-OLV trial.

Background

Postoperative pulmonary complications (PPCs) are a significant concern in thoracic surgery. A modifiable factor influencing PPCs is postoperative residual neuromuscular block (NMB), which impairs respiratory muscle function.

Methods

We performed a post hoc Bayesian analysis...
S-EPMC12597387 | biostudies-literature
UnknownValidation of the RIM Score-COVID in the Spanish SEMI-COVID-19 Registry.
The significant impact of COVID-19 worldwide has made it necessary to develop tools to identify patients at high risk of severe disease and death. This work aims to validate the RIM Score-COVID in the SEMI-COVID-19 Registry. The RIM Score-COVID is a simple nomogram with high predictive capacity for ...
S-EPMC9862219 | biostudies-literature
UnknownImpact of SARS-CoV-2 infection therapies on the risk of venous thromboembolism and cardiovascular events from the SEMI-COVID-19 Registry.
This study aimed to assess the impact of SARS-CoV-2 therapies on the risk of venous thromboembolism (VTE) and other cardiovascular events. A retrospective, multicenter, observational study included hospitalized patients in Spain due to acute SARS-CoV-2 infection from March 2020 to March 2022. A tota...
S-EPMC11882944 | biostudies-literature
UnknownPreventive strategies and factors associated with surgically treated necrotising enterocolitis in extremely preterm infants: an international unit survey linked with retrospective cohort data analysis.
OBJECTIVES:To compare necrotising enterocolitis (NEC) prevention practices and NEC associated factors between units from eight countries of the International Network for Evaluation of Outcomes of Neonates, and to assess their association with surgical NEC rates. DESIGN:Prospective unit-level survey ...
S-EPMC6797308 | biostudies-literature
UnknownApixaban to Prevent Recurrence After Cryptogenic Stroke in Patients With Atrial Cardiopathy: The ARCADIA Randomized Clinical Trial.

Importance

Atrial cardiopathy is associated with stroke in the absence of clinically apparent atrial fibrillation. It is unknown whether anticoagulation, which has proven benefit in atrial fibrillation, prevents stroke in patients with atrial cardiopathy and no atrial fibrillation.

Object...

S-EPMC10851142 | biostudies-literature
UnknownMortality after surgery in Europe: a 7 day cohort study.

Background

Clinical outcomes after major surgery are poorly described at the national level. Evidence of heterogeneity between hospitals and health-care systems suggests potential to improve care for patients but this potential remains unconfirmed. The European Surgical Outcomes Study was an...
S-EPMC3493988 | biostudies-literature
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