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UnknownLiver injury in non-alcoholic fatty liver disease is associated with urea cycle enzyme dysregulation.
The main aim was to evaluate changes in urea cycle enzymes in NAFLD patients and in two preclinical animal models mimicking this entity. Seventeen liver specimens from NAFLD patients were included for immunohistochemistry and gene expression analyses. Three-hundred-and-eighty-two biopsy-proven NAFLD...
S-EPMC8888708 | biostudies-literature
UnknownThe biochemical pattern defines MASLD phenotypes linked to distinct histology and prognosis.

Background

MASLD can manifest as hepatocellular damage, which can result in mild elevation of aminotransferases. However, in some patients, MASLD presents with cholestatic pattern.

Objective

To assess the impact of the biochemical pattern on the natural course of MASLD, including live...
S-EPMC11217049 | biostudies-literature
UnknownModulation of host lipid metabolism by hepatitis C virus: Role of new therapies.
It is well established that hepatitis C virus (HCV) infection and replication relies on host lipid metabolism. HCV proteins interact and associate with lipid droplets to facilitate virion assembly and production. Besides, circulating infective particles are associated with very low-density lipoprote...
S-EPMC4600579 | biostudies-literature
UnknownSystematic review and meta-analysis: analysis of variables influencing the interpretation of clinical trial results in NAFLD.

Background

NAFLD clinical trials have shown suboptimal results, particularly for liver fibrosis, despite the robust preclinical drug development. We aimed to assess the histological response after the experimental treatment versus placebo by carrying out a meta-analysis of NAFLD clinical tri...
S-EPMC9016009 | biostudies-literature
UnknownMultiomics integration unveils photoperiodic plasticity in the molecular rhythms of marine phytoplankton.
Earth's tilted rotation and translation around the Sun produce pervasive rhythms on our planet, giving rise to photoperiodic changes in diel cycles. Although marine phytoplankton plays a key role in ecosystems, multiomics analysis of its responses to these periodic environmental signals remains larg...
S-EPMC12216367 | biostudies-literature
UnknownEffectiveness and safety of first-generation protease inhibitors in clinical practice: Hepatitis C virus patients with advanced fibrosis.

Aim

To evaluates the effectiveness and safety of the first generation, NS3/4A protease inhibitors (PIs) in clinical practice against chronic C virus, especially in patients with advanced fibrosis.

Methods

Prospective study and non-experimental analysis of a multicentre cohort of 38 Sp...
S-EPMC4533049 | biostudies-literature
TranscriptomicsIdentification of MAX signature on MAX deficient SCLC cell lines
To development our gene expression approach, we have employed whole genome microarray expression profiling as a discovery platform to identify genes potentialy regulated by the transcription factor MAX.Human SCLC cell lines waere analyzed for mutations at the MAX locus. Those cell lines that were f...
ORGANISM(S): Homo sapiens 
2013-12-28 | E-GEOD-48559 | biostudies-arrayexpress
UnknownExamining the validity and consistency of the Adult Eating Behaviour Questionnaire-Espanol (AEBQ-Esp) and its relationship to BMI in a Mexican population.

Purpose

Appetitive traits in adults and their associations with weight can be measured using the Adult Eating Behaviour Questionnaire (AEBQ). The aim of this study was to confirm the factor structure of the Spanish AEBQ (AEBQ-Esp) in a Mexican sample and explore associations between the eigh...
S-EPMC8933343 | biostudies-literature
UnknownSafety and Cross-Neutralizing Immunity Against SARS-CoV-2 Omicron Sub-Variant After a Booster Dose with SOBERANA<sup>®</sup> Plus in Children and Adolescents.
Background: With the emergence of SARS-CoV-2 Omicron sub-variants exhibiting increased transmissibility and immune escape, booster immunization is recommended. Ideally, vaccination across all age groups, including children and adolescents, is critical to control viral spread and reduce varian...
S-EPMC12737616 | biostudies-literature
UnknownA Comparative Study of Ultrasmall Calcium Carbonate Nanoparticles for Targeting and Imaging Atherosclerotic Plaque.
Atherosclerosis is a complex disease that can lead to life-threatening events, such as myocardial infarction and ischemic stroke. Despite the severity of this disease, diagnosing plaque vulnerability remains challenging due to the lack of effective diagnostic tools. Conventional diagnostic protocols...
S-EPMC10900527 | biostudies-literature
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