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ProteomicsIdentification of RON13 binding with with RON4 substrate
Active host cell invasion by the obligate intracellular apicomplexan parasites relies on the formation of a moving junction (MJ), which joins parasite and host cell plasma membranes during entry. Invading Toxoplasma gondii tachyzoites secrete a complex of RON proteins from the rhoptry organelles tha...
ORGANISM(S): Toxoplasma gondii GT1 
2021-05-10 | PXD023791 | Pride
Ron13 Toxoplasma gondii Secretory pathway Hdx-ms Kinase 
ProteomicsTarget identification of the novel Toxoplasma gondii rhoptry kinase RON13
The Toxoplasma gondii rhoptry neck protein RON13 was first identified as a substrate of aspartyl protease 3 by Terminal Amine Isotopic Labelling of Substrates (TAILS8, Dogga et al. 2017). It harbours a kinase domain the activity of which is important for host cell invasion. To identify the targets o...
ORGANISM(S): Toxoplasma gondii RH 
2021-05-13 | PXD018056 | Pride
Rhoptry Toxoplasma gondii Kinase Lc-ms/ms 
UnknownStructural insights into an atypical secretory pathway kinase crucial for Toxoplasma gondii invasion.
Not available
S-EPMC8213820 | biostudies-literature
ProteomicsStrucuture-function relationships of an atypical secretory kinase essential for Toxoplasma gondii invasion
An essential step in active host cell invasion by the obligate intracellular apicomplexan parasites is the formation of a moving junction (MJ), which joins both plasma membranes and connects the underlying host cortical cytoskeleton with the parasite actomyosin system. Invading Toxoplasma gondii sec...
ORGANISM(S): Toxoplasma gondii GT1 
2021-05-11 | PXD021516 | Pride
Toxoplasma gondii kinase ron complex invasion 
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