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ProteomicsMapping the SLP76 interactome in T cells lacking each of the GRB2-family adaptors reveals molecular plasticity of the TCR signaling pathway
The propagation of intracellular T cell receptor (TCR) signals involved various adapter proteins that are important molecular switches to connect proteins together. The global characterization of changes in protein-protein interactions following genetic perturbations is critical to understand the re...
ORGANISM(S): Homo sapiens (Human) 
2023-03-13 | PXD038891 | Pride
Ap-ms T cell Slp76 Grb2-family adaptors 
TranscriptomicsQuantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub
The aim of the dataset was to study on a genome-wide level the impact of Lat deficiency on gene expression in resting and activated CD4+ T cells Lat+ and Lat? CD4+ T cells were isolated from lymph nodes and spleen of Latfl-dtr Tmat-Cre mice using a Dynabeads untouched mouse CD4 cells kit (Life Techn...
ORGANISM(S): Mus musculus 
2014-03-02 | E-GEOD-49507 | biostudies-arrayexpress
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