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ProteomicsSLP76 interactome in resting and activated primary mast cells
We used a knock-in (KI) mouse expressing SLP-76 with a C-terminal One-Strep-Tag (OST). Such a system allowed the replacement in the genome of SLP-76 by its tagged version and its expression in physiological amounts. Then, by combining high affinity purification and label-free quantitative proteomics...
ORGANISM(S): Mus musculus (Mouse) 
2013-08-28 | PXD000052 | Pride
Interactomics Slp76 Quantitative mass spectrometry 
ProteomicsMapping the SLP76 interactome in T cells lacking each of the GRB2-family adaptors reveals molecular plasticity of the TCR signaling pathway
The propagation of intracellular T cell receptor (TCR) signals involved various adapter proteins that are important molecular switches to connect proteins together. The global characterization of changes in protein-protein interactions following genetic perturbations is critical to understand the re...
ORGANISM(S): Homo sapiens (Human) 
2023-03-13 | PXD038891 | Pride
Ap-ms T cell Slp76 Grb2-family adaptors 
UnknownMolecular mechanisms underlying the evolution of the slp76 signalosome.
Not available
S-EPMC5431462 | biostudies-literature
UnknownCbl enforces an SLP76-dependent signaling pathway for T cell differentiation.
Not available
S-EPMC2640981 | biostudies-literature
UnknownInherited SLP76 deficiency in humans causes severe combined immunodeficiency, neutrophil and platelet defects.
Not available
S-EPMC7690938 | biostudies-literature
UnknownTargeting SLP76:ITK interaction separates GVHD from GVL in allo-HSCT.
Not available
S-EPMC8024657 | biostudies-literature
UnknownSerine Phosphorylation of SLP76 Is Dispensable for T Cell Development but Modulates Helper T Cell Function.
Not available
S-EPMC5249077 | biostudies-literature
ProteomicsPhosphoproteomics study of N-terminal tyrosine sites of SLP-76
Glocal dynamics of TCR signaling in Jurkat cell lines in SLP76 wild type cells and SLP76 Y3F mutant cells was studied by using LC-MSMS.
ORGANISM(S): Homo sapiens (Human) 
2014-10-15 | PXD001094 | Pride
Phosphorylation Tcr signaling Jurkat Silac Slp-76 Proteomics 
UnknownComplementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76.
Not available
S-EPMC2323515 | biostudies-literature
UnknownSLP76 integrates into the B-cell receptor signaling cascade in chronic lymphocytic leukemia cells and is associated with an aggressive disease course.
Not available
S-EPMC5479607 | biostudies-literature
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