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GenomicsTLX1 ChIP-Seq in ALL-SIL
The T-cell leukemia homeobox 1 (TLX1, HOX11) transcription factor is critically involved in the multistep pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) and often cooperates with NOTCH1 activation during malignant T-cell transformation. However, the exact molecular mechanisms by which t...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-62264 | biostudies-arrayexpress
TranscriptomicsGene expression changes in U937 cells in response to ectopic expression of EVI1 and/or etoposide treatment
Overexpression of ecotropic viral integration site 1 (EVI1) is associated with aggressive disease in acute myeloid leukemia (AML). Despite of its clinical importance, little is known about the mechanism through which EVI1 confers resistance to antileukemic drugs. Here, we show that a human myeloid c...
ORGANISM(S): Homo sapiens 
2015-03-10 | GSE66660 | GEO
TranscriptomicsGene expression changes in U937 cells in response to ectopic expression of EVI1 and/or etoposide treatment
Overexpression of ecotropic viral integration site 1 (EVI1) is associated with aggressive disease in acute myeloid leukemia (AML). Despite of its clinical importance, little is known about the mechanism through which EVI1 confers resistance to antileukemic drugs. Here, we show that a human myeloid c...
ORGANISM(S): Homo sapiens 
2015-03-10 | E-GEOD-66660 | biostudies-arrayexpress
UnknownKLHL12 Promotes Non-Lysine Ubiquitination of the Dopamine Receptors D4.2 and D4.4, but Not of the ADHD-Associated D4.7 Variant.
Not available
S-EPMC4738440 | biostudies-literature
GenomicsH3K27ac ChIP-Seq in ALL-SIL
The T-cell leukemia homeobox 1 (TLX1, HOX11) transcription factor is critically involved in the multistep pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) and often cooperates with NOTCH1 activation during malignant T-cell transformation. However, the exact molecular mechanisms by which t...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-70734 | biostudies-arrayexpress
UnknownA high-throughput 3' UTR reporter screening identifies microRNA interactomes of cancer genes.
Not available
S-EPMC5844555 | biostudies-literature
TranscriptomicsDevelopment of gene expression signatures for GSI treatment of the ALL-SIL cell line.
The T-cell leukemia homeobox 1 (TLX1, HOX11) transcription factor is critically involved in the multistep pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) and often cooperates with NOTCH1 activation during malignant T-cell transformation. However, the exact molecular mechanisms by which t...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-70629 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures of 64 T-ALL patient samples
The T-cell leukemia homeobox 1 (TLX1, HOX11) transcription factor is critically involved in the multistep pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) and often cooperates with NOTCH1 activation during malignant T-cell transformation. However, the exact molecular mechanisms by which t...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-62131 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures for JQ1 treatment of the ALL-SIL cell line.
The T-cell leukemia homeobox 1 (TLX1, HOX11) transcription factor is critically involved in the multistep pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) and often cooperates with NOTCH1 activation during malignant T-cell transformation. However, the exact molecular mechanisms by which t...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-62139 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures for RUNX1 knockdown in the ALL-SIL cell line.
The T-cell leukemia homeobox 1 (TLX1, HOX11) transcription factor is critically involved in the multistep pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) and often cooperates with NOTCH1 activation during malignant T-cell transformation. However, the exact molecular mechanisms by which t...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-62140 | biostudies-arrayexpress
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