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ProteomicsAn AMP-activated protein kinase-PGC-1α axis mediates metabolic plasticity in glioblastoma
Glioblastoma, the most frequent primary malignant brain tumor in adults, is characterized by profound yet dynamic hypoxia and nutrient depletion. To sustain survival and proliferation, tumor cells are compelled to acquire metabolic plasticity with the induction of adaptive metabolic programs. We hav...
ORGANISM(S): Homo sapiens (Human) 
2025-01-19 | PXD046679 | Pride
Amp-kinase Pgc-1α Ppargc1a Hypoxia Glioblastoma Metabolic plasticity Tumor microenvironment 
ProteomicsAMP-kinase mediates adaptation of glioblastoma cells to conditions of the tumour microenvironment
Proteomic analysis of LNT-299 cells.In this experimental study, we investigated the role of the AMPK-mediated stress response in human GB cells. Mimicking the conditions of the tumour microenvironment we deprived GB cells of glucose and oxygen to characterize metabolic effects and to delineate the r...
ORGANISM(S): Homo sapiens (Human) 
2024-12-02 | PXD055976 | Pride
Glioblastoma Tmt Ampk Lc-ms/ms 
UnknownTargetable ERBB2 mutations identified in neurofibroma/schwannoma hybrid nerve sheath tumors.
Not available
S-EPMC7190903 | biostudies-literature
UnknownINTERCEPT H3: a multicenter phase I peptide vaccine trial for the treatment of H3-mutated diffuse midline gliomas.
Not available
S-EPMC10585906 | biostudies-literature
UnknownQuality of life in the GLARIUS trial randomizing bevacizumab/irinotecan versus temozolomide in newly diagnosed, MGMT-nonmethylated glioblastoma.
Not available
S-EPMC6007398 | biostudies-literature
UnknownThe clinical and molecular landscape of diffuse hemispheric glioma, H3 G34-mutant.
Not available
S-EPMC12309718 | biostudies-literature
UnknownGlobal wealth disparities drive adherence to COVID-safe pathways in head and neck cancer surgery.
Not available
S-EPMC8711291 | biostudies-literature
UnknownPancreatic surgery outcomes: multicentre prospective snapshot study in 67 countries.
Not available
S-EPMC10771125 | biostudies-literature
UnknownOutcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic.
Not available
S-EPMC7753519 | biostudies-literature
UnknownMachine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score.
Not available
S-EPMC8344569 | biostudies-literature
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