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UnknownCirculating anti-citrullinated protein antibodies containing secretory component are prognostic for arthritis onset in at-risk patients.
Autoantibodies related to rheumatoid arthritis (RA), such as anti-citrullinated protein antibodies (ACPA), are often detectable in the preclinical period years before arthritis onset. However, events triggering arthritis development remain incompletely known. We aimed to determine whether ACPA isoty...
S-EPMC8119868 | biostudies-literature
UnknownPresence of salivary IgA anti-citrullinated protein antibodies associate with higher disease activity in patients with rheumatoid arthritis.

Background

Circulating IgA anti-citrullinated protein antibodies (ACPA) associate with more active disease, but a previous study implied that salivary IgA ACPA is related to a less severe disease. Therefore, we aimed to characterize the IgA ACPA response in the saliva and serum in relation t...
S-EPMC7681967 | biostudies-literature
UnknownElevated free secretory component in early rheumatoid arthritis and prior to arthritis development in patients at increased risk.

Objectives

Considering growing evidence of mucosal involvement in RA induction, this study investigated circulating free secretory component (SC) in patients with either recent-onset RA or with ACPA and musculoskeletal pain.

Methods

Two prospective cohorts were studied: TIRA-2 compris...
S-EPMC7850007 | biostudies-literature
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