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UnknownMolecular reflex testing in patients with early metastatic castration-resistant prostate cancer within the PROMPT-study.

Background

Precision oncology using genotype-matched treatments (GMT) offers potential to improve survival in metastatic castration-resistant prostate cancer (mCRPC).

Patient and methods

In the PROMPT study (NCT04746300), reflex tumour testing through next-generation sequencing was pe...
S-EPMC12820098 | biostudies-literature
UnknownAntioxidant Treatment and the Chance to Conceive in Men Seeking Fertility Care: The SUMMER Randomized Clinical Trial.

Importance

Treatments for men seeking fertility care are limited. Antioxidant supplements have been widely studied as a new treatment option, but these studies have had conflicting results.

Objective

To assess whether treatment of men seeking fertility care with an antioxidant supplem...
S-EPMC12464787 | biostudies-literature
UnknownLow natalizumab trough concentrations are associated with reduced seroconversion of the John Cunningham virus in natalizumab-treated patients with multiple sclerosis.

Background

Natalizumab is a highly effective drug for patients with relapsing-remitting multiple sclerosis (MS). A disadvantage of this treatment is the risk of progressive multifocal leukoencephalopathy in patients who are seropositive for the John Cunningham virus (JCV). JCV seroconversion...
S-EPMC12573372 | biostudies-literature
UnknownSeroprevalence of SARS-CoV-2 antibodies among healthcare workers in Dutch hospitals after the 2020 first wave: a multicentre cross-sectional study with prospective follow-up.

Background

We aimed to estimate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence and describe its determinants and associated symptoms among unvaccinated healthcare workers (HCWs) after the first wave of the pandemic.

Methods

HCWs from 13 Dutch hospitals...
S-EPMC10688070 | biostudies-literature
UnknownSurvival of patients with deficient mismatch repair metastatic colorectal cancer in the pre-immunotherapy era.

Background

Metastatic colorectal cancer patients with deficient mismatch repair (dMMR mCRC) benefit from immunotherapy. Interpretation of the single-arm immunotherapy trials is complicated by insignificant survival data during systemic non-immunotherapy. We present survival data on a large, ...
S-EPMC7852682 | biostudies-literature
UnknownSome Patients Are More Equal Than Others: Variation in Ventilator Settings for Coronavirus Disease 2019 Acute Respiratory Distress Syndrome.

Objectives

As coronavirus disease 2019 is a novel disease, treatment strategies continue to be debated. This provides the intensive care community with a unique opportunity as the population of coronavirus disease 2019 patients requiring invasive mechanical ventilation is relatively homogene...
S-EPMC8522869 | biostudies-literature
Unknowncfr and fexA genes in methicillin-resistant Staphylococcus aureus from humans and livestock in the Netherlands.

Background

Although the Netherlands is a country with a low endemic level of methicillin-resistant Staphylococcus aureus (MRSA), a national MRSA surveillance has been in place since 1989. In 2003 livestock emerged as a major reservoir of MRSA and currently livestock-associated MRSA (c...
S-EPMC9616846 | biostudies-literature
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