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MetabolomicsUntargeted LC-MS metabolomic studies of Asteraceae species to discover inhibitors of Leishmania major dihydroorotate dehydrogenase

INTRODUCTION: Interesting data about the family Asteraceae as a new source of Leishmania major dihydroorotate dehydrogenase (LmDHODH) inhibitors are presented. This key macromolecular target for parasites causing neglected diseases catalyzes the fourth reaction of the de novo pyr...

2019-10-14 | MTBLS722 | MetaboLights
TranscriptomicsTranscription profiling of Salmonella enterica serovar Typhimurium hha ydgT mutants
transcriptomic analysis of hha ydgT mutants in Salmonella enterica serovar Typhimurium
ORGANISM(S): Salmonella typhimurium 
2008-01-01 | E-MEXP-1303 | biostudies-arrayexpress
TranscriptomicsRNA-seq of in vitro-generated murine T helper 17 cells
T helper (Th) 17 cells form a T cell subset which is crucial to maintain immunity against extracellular bacteria and fungi at epithelial barriers, but Th17 cells are also enriched at sites of inflammation in autoimmune disease. These sites are commonly characterised by adverse environmental conditio...
ORGANISM(S): Mus musculus 
2017-06-14 | E-MTAB-5692 | biostudies-arrayexpress
TranscriptomicsExpression data from Saccharomyces cerevisiae strains deleted for the THSC/TREX-2 subunits Thp1, Sac3 and Sus1
Transcription is a major obstacle for replication fork progression and a cause of genome instability. Such instability increases in mutants with a suboptimal assembly of the nascent messenger ribonucleo-protein particle (mRNP), as THO/TREX and the NPC-associated THSC/TREX-2 complex. We used microarr...
ORGANISM(S): Saccharomyces cerevisiae 
2014-10-08 | E-GEOD-56702 | biostudies-arrayexpress
UnknownInflammation scores based on C-reactive protein and albumin predict mortality in hospitalized older patients independent of the admission diagnosis.
Not available
S-EPMC11463076 | biostudies-literature
UnknownInvolvement of SYCP2L and TDRD3 gene variants on ovarian reserve and reproductive outcomes: a cross-sectional study.
Not available
S-EPMC10712833 | biostudies-literature
ProteomicsGenomic exaptation and regulatory landscape shifts as key mechanisms enabling flatworm terrestrialization
Understanding the genomic toolkit that enabled animal terrestrialization, the shift from aquatic to terrestrial habitats, is key to uncovering the evolutionary origins of land biodiversity. Yet, the genomic basis of the physiological and metabolic adaptations required for life on land remains poorly...
ORGANISM(S): Obama nungara Schmidtea mediterranea (Freshwater planarian flatworm) 
2026-04-06 | PXD074775 | Pride
Planarians Evolution Flatworm Terrestrialization 
ProteomicsLack of a universal genomic toolkit for animal terrestrialisation
Animal terrestrialisation, the transition from aquatic to land environments, is one of the most impactful events in animal evolution, having occurred independently across several phyla. Yet, whether these transitions relied on a conserved genomic toolkit remains unexplored. To address this gap, we i...
ORGANISM(S): Obama nungara Siphonaria pectinata Leptonemertes chalicophora Lineus sanguineus Schmidtea mediterranea (Freshwater planarian flatworm) Litoditis marina Eisenia fetida Phorcus turbinatus Caenorhabditis elegans Theba pisana Porcellio scaber Ligia oceanica Physella Hirudo medicinalis Arenicola marina Ooperipatellus viridimaculatus 
2026-06-15 | PXD064337 | Pride
Proteomics Terrestrialization 
TranscriptomicsTranscription profiling of mouse mammary tumours developed in Wap-Cre;Etv6-NTRK3 mice
We report a mouse model that recapitulates expression of the ETV6-NTRK3 (EN) fusion oncoprotein, the product of the t(12;15)(p13;q25) translocation characteristic of human secretory breast carcinoma. Activation of EN expression in mammary tissues by Whey acidic protein (Wap) promoter-driven Cre lead...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9355 | biostudies-arrayexpress
UnknownDisconnecting the Golgi ribbon from the centrosome prevents directional cell migration and ciliogenesis
Not available
S-JCBD-201011014 | bioimages
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