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ProteomicsTranscriptome and phosphoproteome analyses of gemcitabine-resistant gallbladder cancer cells provide novel insights into molecular changes occurring during acquired resistance
Treatment options for advanced gallbladder cancer (GBC) are scarce and usually rely on cytotoxic chemotherapy, but unfortunately the effectiveness of any regimen is limited, and recurrence rates are high. Here, we established and characterized two gemcitabine-resistant GBC cell sublines (NOZ GemR an...
ORGANISM(S): Homo sapiens (Human) 
2023-05-03 | PXD036348 | Pride
Gemcitabine resistance Gallbladder cancer 
TranscriptomicsIn vitro caloric restriction induces protective genes and functional rejuvenation in senescent SAMP8 astrocytes
Astrocytes are key cells in brain aging, helping neurons to undertake healthy aging or otherwise letting them enter into a spiral of neurodegeneration. We aimed to characterize astrocytes cultured from senescence-accelerated prone 8 (SAMP8) mice, a mouse model of brain pathological aging, along with...
ORGANISM(S): Mus musculus 
2015-06-23 | E-GEOD-60388 | biostudies-arrayexpress
ProteomicsNeddylation inhibition halts acetaminophen induced liver injury boosting anabolic cardiolipin pathway
Drug Induced-liver injury (DILI) is a significant cause of acute liver failure (ALF) and liver transplantation in the Western world. APAP overdose is a main contributor of DILI, leading to hepatocyte cell death through necrosis. Herein, we identified that neddylation, an essential post-translational...
ORGANISM(S): Mus Musculus 
2024-06-18 | PXD053221 |
TranscriptomicsTranscriptional profiling of fetal hypothalamic TRH neurons
During murine hypothalamic development, different neuroendocrine cell phenotypes are generated in overlapping periods; this suggests that cell-type specific developmental programs operate to achieve complete maturation. A balance between programs that include cell proliferation, cell cycle withdrawa...
ORGANISM(S): Rattus norvegicus 
2011-05-27 | E-GEOD-28441 | biostudies-arrayexpress
UnknownChanges in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D.
Not available
S-EPMC9008199 | biostudies-literature
TranscriptomicsExpression data from FAK null mouse embryonic fibroblasts treated with endothelin-1
Endothelin-1 (ET-1) plays a critical role in connective tissue remodeling by fibroblasts during tissue repair and fibrosis. We investigated the molecular pathways in the transmission of ET-1 signals that lead to features of connective tissue remodeling, in particular the role of FAK (focal adhesion ...
ORGANISM(S): Mus musculus 
2012-06-30 | E-GEOD-30356 | biostudies-arrayexpress
TranscriptomicsBasal expression in daDREAM transgenic mouse hippocampus
Changes in nuclear Ca2+ homeostasis activate specific gene expression programs and are central to the acquisition and the plastic storage of memories. DREAM /KChIP proteins form heterotetramers that bind DNA and repress transcription in a Ca2+-dependent manner. Single ablation of one member of the D...
ORGANISM(S): Mus musculus 
2012-04-24 | E-GEOD-17844 | biostudies-arrayexpress
UnknownMortality after surgery in Europe: a 7 day cohort study.
Not available
S-EPMC3493988 | biostudies-literature
UnknownElective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans.
Not available
S-EPMC7272903 | biostudies-literature
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