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ProteomicsThe cyclin dependent kinase inhibitor Roscovitine reverses diet-induced metabolic disruption in obese mice
We show that roscovitine; a cyclin-dependent kinases inhibitor; given to mice during the last six weeks of a 19-week high fat diet, reduced weight gain and prevented accompanying insulin resistance, hepatic steatosis, visceral adipose tissue (eWAT) inflammation and fibrosis. It also restored insulin...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-03 | PXD027981 | Pride
Proteomics Obesity Adipose mitochondria Therapy Roscovitine 
GenomicsR-Roscovitine improves motoneuron function in mouse models for Spinal Muscular Atrophy.
R-Roscovitine improves motoneuron function in mouse models for Spinal Muscular Atrophy.
PRJNA448923 | ENA
TranscriptomicsR-Roscovitine improves motoneuron function in mouse models for Spinal Muscular Atrophy.
Neurotransmission defects and motoneuron degeneration are hallmarks of Spinal Muscular Atrophy, a monogenetic disease caused by the deficiency of the SMN protein. In the present study, we show that systemic application of R-Roscovitine - a Cav2.1 / Cav2.2 channel modifier and a Cyclin-dependent kina...
ORGANISM(S): Mus musculus 
2020-01-28 | GSE112771 | GEO
TranscriptomicsEffects of T350 phospho- on gene repression activity of EZH2
The Polycomb group (PcG) protein enhancer of zeste homolog 2 (EZH2) plays an essential role in histone methylation-mediated epigenetic gene silencing. We demonstrate that under physiological conditions, cyclin-dependent kinase 1 (CDK1) and 2 (CDK2) bind to and phosphorylate EZH2 at threonine 350 (T3...
ORGANISM(S): Homo sapiens 
2010-11-02 | E-GEOD-20433 | biostudies-arrayexpress
UnknownRoscovitine in cancer and other diseases.
Not available
S-EPMC4486920 | biostudies-literature
UnknownAntifibrotic effects of roscovitine in normal and scleroderma fibroblasts.
Not available
S-EPMC3502367 | biostudies-literature
UnknownRoscovitine inhibits CaV3.1 (T-type) channels by preferentially affecting closed-state inactivation.
Not available
S-EPMC3263959 | biostudies-literature
UnknownR-Roscovitine Improves Motoneuron Function in Mouse Models for Spinal Muscular Atrophy.
Not available
S-EPMC6992996 | biostudies-literature
UnknownRoscovitine inhibits EBNA1 serine 393 phosphorylation, nuclear localization, transcription, and episome maintenance.
Not available
S-EPMC3067954 | biostudies-literature
UnknownRoscovitine Worsens Mycobacterium abscessus Infection by Reducing DUOX2-mediated Neutrophil Response.
Not available
S-EPMC8990120 | biostudies-literature
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