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TranscriptomicsSingle cell RNAseq analysis of anti-Vaccinia long-lived memory B cells (CEL-seq2)
Memory B cells represent one of the pillar of humoral protection and are found in the circulation and secondary lymphoid organs several decades after initial pathogen or vaccine encounter. The exact cellular and biological mechanisms allowing long-term survival of quiescent cells in such a fluctuati...
ORGANISM(S): Homo sapiens 
2022-09-19 | E-MTAB-11626 | biostudies-arrayexpress
UnknownPhase I Study Evaluating WEE1 Inhibitor AZD1775 As Monotherapy and in Combination With Gemcitabine, Cisplatin, or Carboplatin in Patients With Advanced Solid Tumors.
Not available
S-EPMC7845944 | biostudies-literature
UnknownImmobilization of a TiO2-PEDOT:PSS hybrid heterojunction photocatalyst for degradation of organic effluents.
Not available
S-EPMC9850944 | biostudies-literature
TranscriptomicsImpact of Hells loss-of-function on DNA methylation in B cells during humoral immune responses: kinetic comparison of Mb1-Hells knockout and control mice by single-cell RNA sequencing
We are interested in deciphering the mechanism by which DNA methylation in late B cell differentiation affects humoral immune response. We chose to study a very rare immunodeficiency called ICF type 4, where a point mutation in a gene encoding the protein HELLS causes a lack of both circulating anti...
ORGANISM(S): Mus musculus 
2023-07-25 | E-MTAB-12499 | biostudies-arrayexpress
TranscriptomicsScRNA-seq analysis of naive, germinal center and memory B cells of mice immunized with homologous and heterologous prime:boost combinations of whole-cell pertussis or acellular pertussis vaccines
Since the introduction of new generation pertussis vaccines, resurgence of pertussis is observed in many developed countries. Former whole-cell pertussis vaccines (wP) are able to protect against disease and transmission but have been replaced in several industrialized countries because of their rea...
ORGANISM(S): Mus musculus 
2022-09-12 | E-MTAB-12156 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse mammary gland side population cells (MG-SPs) to identify differentially expressed genes.
Similar to the bone marrow, the mammary gland contains a distinct population of Hoechst-effluxing side population cells, MG-SPs. To better characterize MG-SPs, their microarray gene profiles were compared to the remaining cells, which retain Hoechst dye (MG-NSPs). For analysis, gene ontology (GO) t...
ORGANISM(S): Mus musculus 
2007-11-27 | E-GEOD-5309 | biostudies-arrayexpress
TranscriptomicsCharacterising the transcriptional profile of murine 3T3-L1 adipocytes with altered expression of IRF3.
The chronic inflammatory state that accompanies obesity is a major contributor to insulin resistance and other metabolic dysfunction features. Despite recent advances in our understanding of the cellular and secreted factors that promote the inflammatory milieu of obesity, we have much less insight ...
ORGANISM(S): Mus musculus 
2016-05-31 | E-GEOD-81193 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse mammary tumor-initiating cells
Using a syngeneic p53 null mouse mammary gland tumor model that closely mimics human breast cancer, we have identified by limiting dilution transplantation as well as in vitro mammosphere and clonogenic assays a Lin-CD29HighCD24High subpopulation of tumor-initiating cells. Differentially expressed ...
ORGANISM(S): Mus musculus 
2008-10-18 | E-GEOD-8863 | biostudies-arrayexpress
UnknownRespiratory Syncytial Virus Prefusion F Protein Vaccine Is Efficacious in Older Adults With Underlying Medical Conditions.
Not available
S-EPMC10810713 | biostudies-literature
UnknownCognitive subtypes in recent onset psychosis: distinct neurobiological fingerprints?
Not available
S-EPMC8209013 | biostudies-literature
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