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TranscriptomicsMAQC
The MicroArray Quality Control (MAQC) project was initiated to address these concerns, as well as other performance and analysis issues. We demonstrate the consistency of results within a platform across test sites as well as the high level of cross-platform concordance in terms of genes identified ...
ORGANISM(S): Homo sapiens 
2006-12-04 | E-TABM-132 | biostudies-arrayexpress
MetabolomicsFeatures of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study
Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficit...
2024-01-12 | MTBLS850 | MetaboLights
TranscriptomicsStem Cell Antigen-1 (Sca-1) Regulates Mammary Tumor Development and Cell Migration
Stem cell antigen-1 (Sca-1 or Ly6A) is a member of the Ly6 family of glycosyl phostidylinositol (GPI)-anchored cell surface proteins. To determine the potential mechanisms by which Sca-1 regulates cell migration, adhesion, and tumor development; we performed an Affymetrix mouse genome 430A 2.0 array...
ORGANISM(S): Mus musculus 
2012-02-16 | E-GEOD-30684 | biostudies-arrayexpress
TranscriptomicsExpression data from human SGBS adipocytes under hypoxic conditions
Hypoxia in adipose tissue is suggested to be involved in the development of a chronic mild inflammation, which in obesity can further lead to insulin-resistance. The effect of hypoxia on gene expression in adipocytes seems to play a central role in this inflammatory response observed in obesity. How...
ORGANISM(S): Homo sapiens 
2011-04-14 | E-GEOD-28603 | biostudies-arrayexpress
TranscriptomicsExpression data from wild-type and PPARalpha-null mice exposed to perfluorooctane sulfonate (PFOS)
Perfluorooctane sulfonate (PFOS) is a perfluoroalkyl acid (PFAA) and a persistent environmental contaminant found in the tissues of humans and wildlife. Although blood levels of PFOS have begun to decline, health concerns remain because of the long half-life of PFOS in humans. Like other PFAAs, suc...
ORGANISM(S): Mus musculus 
2010-10-01 | E-GEOD-22871 | biostudies-arrayexpress
TranscriptomicsExpression profiling of 3T3-L1 adipogenesis
3T3-L1 pre-adipocyte cells were grown to confluence and induced to differentiate in adipogeneic media. Two technical replicates from four time points relative to induction of adipogenesis (day 0)
ORGANISM(S): Mus musculus 
2010-09-30 | E-GEOD-20696 | biostudies-arrayexpress
TranscriptomicsChanges in follistatin levels by BRCA1 may serve as a regulator of ovarian carcinogenesis
Follistatin is a folliculogenesis regulating protein that has been found in relatively high concentration in the female ovarian tissues. Follistatin acts as an antagonist to the function of Activin, which is often found elevated in ovarian carcinogenesis and thus presents a possibility for therapeut...
ORGANISM(S): Homo sapiens 
2011-07-02 | E-GEOD-30296 | biostudies-arrayexpress
TranscriptomicsExpression profiling of human adipose stromal cell (hASC) adipogenesis
Human abdominal adipose tissue was obtained with informed consent from a 33-year old Caucasian female (BMI = 32.96 Kg/m2) undergoing lipoaspiration. Adipose stromal cells (hASCs) were isolated and differentiated into adipocytes in vitro. Two technical replicates from 9 time points realtive to induct...
ORGANISM(S): Homo sapiens 
2010-09-30 | E-GEOD-20697 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiling of human adipose stromal cell (hASC) adipogenesis
Human abdominal adipose tissue was obtained with informed consent from a 33-year old Caucasian female (BMI = 32.96 Kg/m2) undergoing lipoaspiration. Adipose stromal cells (hASCs) were isolated and differentiated into adipocytes in vitro. Two technical replicates from 9 time points relative to induct...
ORGANISM(S): Homo sapiens 
2010-09-30 | E-GEOD-20699 | biostudies-arrayexpress
TranscriptomicsIntegrative Gene Expression Profiling Reveals G6PD-Mediated Resistance to RNA-Directed Nucleoside Analogues in B-Cell Neoplasms
8-amino-adenosine (8-NH2-Ado) inhibits RNA synthesis and specifically inhibits synthesis of mRNAs with short half-lives. We hypothesize that the mRNAs affected code for proteins important in apoptosis and glucose metabolism. Gene Expression Arrays will help us understand which gene families may be...
ORGANISM(S): Homo sapiens 
2012-05-31 | E-GEOD-38145 | biostudies-arrayexpress
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