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TranscriptomicsExpression of miR-200c in claudin-low breast cancer alters stem cell functionality, enhances chemosensitivity and reduces metastatic potential
Claudin-low tumors are a highly aggressive breast cancer subtype with no targeted treatments and a clinically documented resistance to chemotherapy. They are significantly enriched in cancer stem cells (CSCs), which makes claudin-low tumor models particularly attractive for studying CSC behavior and...
ORGANISM(S): Mus musculus 
2015-06-22 | E-GEOD-62230 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of osteosarcoma tumor-initiating cells (High) vs bulk tumor cells (Low)
In the cancer stem cell model a cell hierarchy has been suggested as an explanation for intratumoral heterogeneity, and tumor formation is thought to be driven by this tumor cell subpopulation. The identification of cancer stem cells in osteosarcoma (OS) and the biological processes dysregulated in ...
ORGANISM(S): Homo sapiens 
2011-11-04 | E-GEOD-33458 | biostudies-arrayexpress
UnknownShort Term Analgesic Effects of 5% Dextrose Epidural Injections for Chronic Low Back Pain: A Randomized Controlled Trial.
Not available
S-EPMC5554430 | biostudies-literature
TranscriptomicsGene expression analyses of C/EBPb knockout in stem/progenitor cell populations
CCAAT/enhancer binding protein beta (C/EBPb) is a member of a family of highly conserved transcription factors that regulates numerous genes involved in proliferation and differentiation in a variety of tissues. C/EBPb is deregulated in human breast cancer and germline deletion of this gene results...
ORGANISM(S): Mus musculus 
2010-02-05 | E-GEOD-16380 | biostudies-arrayexpress
UnknownRor2 regulates branching, differentiation, and actin-cytoskeletal dynamics within the mammary epithelium
Not available
S-JCBD-201408058 | bioimages
TranscriptomicsTranscriptomic Classification of Genetically Engineered Mouse Models of Breast Carcinoma Identifies Human Subtype Counterparts
Background: Human breast cancer is a heterogeneous disease consisting of multiple molecular subtypes. Genetically engineered mouse models (GEMMs) are useful resources for studying breast cancers in vivo under genetically controlled and immune competent conditions. Identifying murine models with cons...
ORGANISM(S): Mus musculus 
2013-11-04 | E-GEOD-42640 | biostudies-arrayexpress
UnknownDominant-negative heterozygous mutations in AIRE confer diverse autoimmune phenotypes.
Not available
S-EPMC10206195 | biostudies-literature
UnknownFactors associated with and kinetics of anti-IFN-α autoantibodies in <i>RAG1/2</i> deficiency.
Not available
S-EPMC12281840 | biostudies-literature
UnknownBroad-spectrum antibodies against self-antigens and cytokines in RAG deficiency.
Not available
S-EPMC4639965 | biostudies-literature
UnknownMultiomics dissection of human RAG deficiency reveals distinctive patterns of immune dysregulation but a common inflammatory signature.
Not available
S-EPMC12087669 | biostudies-literature
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