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TranscriptomicsExpression of miR-200c in claudin-low breast cancer alters stem cell functionality, enhances chemosensitivity and reduces metastatic potential
Claudin-low tumors are a highly aggressive breast cancer subtype with no targeted treatments and a clinically documented resistance to chemotherapy. They are significantly enriched in cancer stem cells (CSCs), which makes claudin-low tumor models particularly attractive for studying CSC behavior and...
ORGANISM(S): Mus musculus 
2015-06-22 | E-GEOD-62230 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of osteosarcoma tumor-initiating cells (High) vs bulk tumor cells (Low)
In the cancer stem cell model a cell hierarchy has been suggested as an explanation for intratumoral heterogeneity, and tumor formation is thought to be driven by this tumor cell subpopulation. The identification of cancer stem cells in osteosarcoma (OS) and the biological processes dysregulated in ...
ORGANISM(S): Homo sapiens 
2011-11-04 | E-GEOD-33458 | biostudies-arrayexpress
TranscriptomicsRelief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF mutant thyroid carcinomas.
Analysis of transcriptome kinetics of SW1736 thyroid cancer cell line vs SK-MEL-28 melanoma cell line at various times after addition of 2 µM vemurafenib. The hypothesis tested was that SW1736 cells (vemurafenib-refractory) differentially express genes compared to SK-MEL-28 cells (vemurafenib sensit...
ORGANISM(S): Homo sapiens 
2013-02-01 | E-GEOD-37441 | biostudies-arrayexpress
UnknownBroad-spectrum antibodies against self-antigens and cytokines in RAG deficiency.
Not available
S-EPMC4639965 | biostudies-literature
UnknownThe risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies.
Not available
S-EPMC9173764 | biostudies-literature
UnknownCommon, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.
Not available
S-EPMC8661833 | biostudies-literature
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