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Transcriptomicssingle cell RNAseq of memory B cells in the context of rituximab-treated ITP patients
Rituximab (RTX) is widely used as a first-line therapeutic strategy in B cell-mediated autoimmune diseases. However, a large proportion of patients either do not respond to the treatment or relapse during B cell reconstitution. Primary immune thrombocytopenia (ITP) is a prototypic B cell mediated au...
ORGANISM(S): Homo sapiens 
2021-01-31 | E-MTAB-9955 | biostudies-arrayexpress
UnknownThird generation quinoline-3-carboxamide transcriptional disrupter of HDAC4, HIF-1α, and MEF-2 signaling for metastatic castration-resistant prostate cancer.
Not available
S-EPMC10559933 | biostudies-literature
TranscriptomicsTranscriptional perturbations caused by tumor virus proteins
Genotypic differences greatly influence susceptibility and resistance to disease. Understanding genotype-phenotype relationships requires that phenotypes be viewed as manifestations of network properties, rather than simply as the result of individual genomic variations. Genome sequencing efforts ha...
ORGANISM(S): Homo sapiens 
2012-07-19 | E-GEOD-38467 | biostudies-arrayexpress
TranscriptomicsIntegrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer.
Abstract BACKGROUND: The basal-like breast cancer (BLBC) subtype is characterized by positive staining for basal mammary epithelial cytokeratin markers, lack of hormone receptor and HER2 expression, and poor prognosis with currently no approved molecularly-targeted therapies. The oncogenic signaling...
ORGANISM(S): Homo sapiens 
2016-08-21 | E-GEOD-74667 | biostudies-arrayexpress
UnknownEfficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine.
Not available
S-EPMC9127773 | biostudies-literature
UnknownSafety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.
Not available
S-EPMC7745181 | biostudies-literature
UnknownSafety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine through 6 Months.
Not available
S-EPMC8461570 | biostudies-literature
UnknownStandard care versus protocol based therapy for new onset Pseudomonas aeruginosa in cystic fibrosis.
Not available
S-EPMC4059359 | biostudies-literature
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