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TranscriptomicsRelief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF mutant thyroid carcinomas.
Analysis of transcriptome kinetics of SW1736 thyroid cancer cell line vs SK-MEL-28 melanoma cell line at various times after addition of 2 µM vemurafenib. The hypothesis tested was that SW1736 cells (vemurafenib-refractory) differentially express genes compared to SK-MEL-28 cells (vemurafenib sensit...
ORGANISM(S): Homo sapiens 
2013-02-01 | E-GEOD-37441 | biostudies-arrayexpress
TranscriptomicsIntegrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer.
Abstract BACKGROUND: The basal-like breast cancer (BLBC) subtype is characterized by positive staining for basal mammary epithelial cytokeratin markers, lack of hormone receptor and HER2 expression, and poor prognosis with currently no approved molecularly-targeted therapies. The oncogenic signaling...
ORGANISM(S): Homo sapiens 
2016-08-21 | E-GEOD-74667 | biostudies-arrayexpress
TranscriptomicsAXL mediates resistance to PI3Kα inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas.
Phosphoinositide-3-kinase (PI3K)-α inhibitors are clinically active in squamous carcinoma (SCC) of the head and neck (H&N) bearing mutations or amplification of PIK3CA. We aimed to identify potential mechanism of resistance and have observed that SCCs cells overcome the antitumor effects of the PI3K...
ORGANISM(S): Homo sapiens 
2015-04-12 | E-GEOD-61515 | biostudies-arrayexpress
UnknownRacial and ethnic differences in prenatal exposure to environmental phenols and parabens in the ECHO Cohort.
Not available
S-EPMC12583149 | biostudies-literature
UnknownHost factors are associated with vaginal microbiome structure in pregnancy in the ECHO Cohort Consortium.
Not available
S-EPMC11116393 | biostudies-literature
UnknownMethods and reproducibility of grading optimized digital color fundus photographs in the Age-Related Eye Disease Study 2 (AREDS2 Report Number 2).
Not available
S-EPMC3706107 | biostudies-literature
UnknownCTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors.
Not available
S-EPMC11560846 | biostudies-literature
UnknownThe Association of Prenatal Dietary Factors with Child Autism Diagnosis and Autism-Related Traits Using a Mixtures Approach: Results from the Environmental Influences on Child Health Outcomes Cohort.
Not available
S-EPMC12264552 | biostudies-literature
UnknownNeighborhood Food Access in Early Life and Trajectories of Child Body Mass Index and Obesity.
Not available
S-EPMC11406455 | biostudies-literature
UnknownPrenatal Diet and Infant Growth From Birth to Age 24 Months.
Not available
S-EPMC11582932 | biostudies-literature
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