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TranscriptomicsAnalysis of colorectal tissue from APC- and MYH-associated polyposis patients
Expression profiling is a well established tool for the genome-wide analysis of the transcriptional activity of human neoplasia. However, the high sensitivity of this approach combined with the well-known cellular and molecular heterogeneity of cancer often result in extremely complex and extended e...
ORGANISM(S): Homo sapiens 
2008-04-01 | E-GEOD-9689 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of breast cancer subtypes are detectable in histologically normal breast epithelium
Background: We hypothesize that important genomic differences between breast cancer subtypes occur early in carcinogenesis. Therefore, gene expression might distinguish histologically normal breast epithelium (NlEpi) from breasts containing estrogen receptor positive (ER+) compared with estrogen rec...
ORGANISM(S): Homo sapiens 
2010-12-07 | E-GEOD-21947 | biostudies-arrayexpress
TranscriptomicsEarly Dysregulation of Cell Adhesion and Extracellular Matrix Pathways in Breast Cancer Progression
Proliferative breast lesions, such as simple ductal hyperplasia (SH) and atypical ductal hyperplasia (ADH), are candidate precursors to ductal carcinoma in situ (DCIS) and invasive cancer. To better understand their relationship to more advanced disease, we used microdissection and DNA microarrays t...
ORGANISM(S): Homo sapiens 
2009-09-08 | E-GEOD-16873 | biostudies-arrayexpress
UnknownPharmacokinetics of oral and intravenous melatonin in healthy volunteers.
Not available
S-EPMC4759723 | biostudies-literature
TranscriptomicsHistologically normal epithelium from breast cancer patients and cancer-free prophylactic mastectomy patients
Gene expression in histologically normal epithelium from breast cancer patients and cancer-free prophylactic mastectomy patients share a similar profile Introduction: We hypothesized that gene expression in histologically normal epithelium (NlEpi) would differ in breast cancer patients (HN) compared...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-20437 | biostudies-arrayexpress
TranscriptomicsIdentification of nine genomic regions of amplification in bladder cancer, correlation with stage, and potential prognositic and therapeutic value
We sought to test the hypothesis that ascertainment of genome-wide copy number alterations in bladder cancer may have value for clinical management. We performed a genome wide analysis of 164 bladder cancer samples and 27 bladder cancer cell lines to identify genetic changes associated with disease ...
ORGANISM(S): Homo sapiens 
2013-04-29 | E-GEOD-44323 | biostudies-arrayexpress
UnknownAn inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging.
Not available
S-EPMC8654267 | biostudies-literature
UnknownT cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial.
Not available
S-EPMC7065359 | biostudies-literature
UnknownScreening Clinical Cell Products for Replication Competent Retrovirus: The National Gene Vector Biorepository Experience.
Not available
S-EPMC6134358 | biostudies-literature
TranscriptomicsCRISPR screen exploring resistance to AKTi (Capivasertib) in ER+ Breast Cancer in MCF7, T47D and CAMA-1 cell lines
A genome-wide CRISPR-Cas9 knockout screen was performed in the breast cancer cell lines T47D, MCF7, and CAMA-1 to identify genes modulating sensitivity and resistance to capivasertib, a selective AKT inhibitor. Cells were transduced with a CRISPR library, followed by treatment with capivasertib or v...
ORGANISM(S): Homo sapiens 
2026-05-25 | E-MTAB-16438 | biostudies-arrayexpress
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