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TranscriptomicsMurine CD8+ Pmel Lymphocytes IL-2 vs. IL-15
Central memory tumor-reactive CD8+ T cells confer superior antitumor immunity compared to effector memory T cells
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-2578 | biostudies-arrayexpress
GenomicsTGF-β attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.
We examined tumours from a large cohort of patients with metastatic urothelial bladder cancer (mUC) treated with an anti–PD-L1 agent (atezolizumab) and identified major determinants of clinical response and immune escape. Whole transcriptome profiles were generated for 368 patients using TruSeq RNA ...
EGAS00001002556 | EGA
UnknownRedistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer.
Not available
S-EPMC4268254 | biostudies-literature
UnknownBRAF Targeting Sensitizes Resistant Melanoma to Cytotoxic T Cells.
Not available
S-EPMC6497575 | biostudies-literature
TranscriptomicsMicroRNA expression profiling of male breast cancer
To test the hypothesis that there is a specific miRNA expression signature which characterizes male breast cancers, we performed miRNA microarray analysis in a series of male breast cancers and compared them to cases of male gynecomastia and female breast cancers miRNA microarray analysis was perfor...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-17155 | biostudies-arrayexpress
UnknownFADD deficiency impairs early hematopoiesis in the bone marrow.
Not available
S-EPMC3119601 | biostudies-literature
UnknownMemory T cell-driven differentiation of naive cells impairs adoptive immunotherapy.
Not available
S-EPMC4701537 | biostudies-literature
Genomicsena-DATASET-GNE-22-02-2018-22:43:32:906-1098 - samples
RNA was extracted from formalin-fixed and paraffin embedded tumors of a large cohort of bladder cancer patients before treatment with anti-PD-L1. RNA was sequenced using a capture based approach (exome capture, RNA access).
EGAD00001003977 | EGA
Genomicsena-DATASET-GNE-27-07-2018-23:28:18:139-1120 - samples
Tumor DNA was extracted from formalin-fixed and paraffin embedded tumors of a large cohort of bladder cancer patients before treatment with anti-PD-L1. Normal DNA was extracted from matched PBMCs. Whole exome sequencing was performed. This is a subset of patients for which RNA sequencing is also pro...
EGAD00001004218 | EGA
UnknownThe pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation.
Not available
S-EPMC3345951 | biostudies-literature
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