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UnknownThoracic and paraspinal extramedullary hematopoiesis in a cat with chronic non-regenerative anemia.
Not available
S-EPMC6144522 | biostudies-literature
ProteomicsAscorbate peroxidase (APEX2) -mediated proximity-based proteomics for HTT protein interactions
Huntington’s Disease (HD), a progressive neurodegenerative disorder with no disease-modifying therapies, is caused by a CAG repeat expansion in the HD gene encoding polyglutamine-expanded huntingtin (HTT) protein. Mechanisms of HD cellular pathogenesis and cellular functions of the normal and mutan...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD059663 | Pride
Huntington’s disease Protein interactions Huntingtin Dna damage Neurodegeneration 
ProteomicsPTMs of HTT protein - Post-translational modifications (PTMs), identified on endogenous huntingtin, cluster within proteolytic domains between HEAT repeats
Post-translational modifications (PTMs) of proteins regulate various cellular processes. PTMs of polyglutamine-expanded huntingtin (Htt) protein, causative of Huntington’s disease (HD), are likely modulators of HD pathogenesis. Previous studies have identified and characterized several PTMs on exo...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-06-29 | PXD005753 | Pride
Huntingtin Hd Human and mouse brain 
ProteomicsHuntingtin interactome in human striatal neurons derived from iPSCs upon the induction of double strand break (DSB) DNA damage response
Huntington’s Disease (HD), a progressive neurodegenerative disorder with no disease-modifying therapies, is caused by a CAG repeat expansion in the HD gene encoding polyglutamine-expanded huntingtin (HTT) protein. Mechanisms of HD cellular pathogenesis and cellular functions of the normal and mutan...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD059660 | Pride
Huntington’s disease Protein interactions Huntingtin Dna damage Neurodegeneration 
TranscriptomicsTranscriptional dysregulation of synaptic genes in a human iPSC model of major mental disorders
Schizophrenia and other psychiatric disorders are postulated to be developmental disorders resulting from synapse dysfunction. How susceptibility genes for major mental disorders could lead to synaptic deficits in humans is not well-understood. Here we generated induced pluripotent stem cells (iPSCs...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-57821 | biostudies-arrayexpress
UnknownDouble-blind, randomized trial of docetaxel plus vandetanib versus docetaxel plus placebo in platinum-pretreated metastatic urothelial cancer.
Not available
S-EPMC4104290 | biostudies-literature
TranscriptomicsTargeting H3K4 methylation as a therapeutic strategy for Huntington's disease (RNA-seq)
Transcriptional dysregulation is an early feature of Huntington's disease (HD). We observed gene-specific changes in H3K4me3 at transcriptionally repressed promoters in R6/2 mouse and human HD brain. Genome-wide analysis showed a novel chromatin signature for this mark. Reducing the levels of the H3...
ORGANISM(S): Mus musculus 
2013-07-18 | E-GEOD-48962 | biostudies-arrayexpress
GenomicsTargeting H3K4 methylation as a therapeutic strategy for Huntington's disease (ChIP-seq)
Transcriptional dysregulation is an early feature of Huntington's disease (HD). We observed gene-specific changes in H3K4me3 at transcriptionally repressed promoters in R6/2 mouse and human HD brain. Genome-wide analysis showed a novel chromatin signature for this mark. Reducing the levels of the H3...
ORGANISM(S): Mus musculus 
2013-07-18 | E-GEOD-48960 | biostudies-arrayexpress
UnknownRandomized phase III multi-institutional study of TNFerade biologic with fluorouracil and radiotherapy for locally advanced pancreatic cancer: final results.
Not available
S-EPMC4820756 | biostudies-literature
GenomicsAn alternative pluripotent state confers interspecies chimaeric competency [WGBS]
In this study, we show that by simple modulation of extrinsic signaling pathways, a new class of pluripotent stem cells, referred to as region selective epiblast stem cells (rsEpiSCs), could be efficiently derived from different stages of the early embryo. rsEpiSCs share features of primed pluripote...
ORGANISM(S): Mus musculus 
2015-05-06 | E-GEOD-63568 | biostudies-arrayexpress
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