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MetabolomicsNQO1 protects obese mice through improvements in glucose and lipid metabolism.
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-...
2024-05-23 | MTBLS2085 | MetaboLights
TranscriptomicsTranscription profiling of human pheochromocytomas of various genetic origins
Pheochromocytomas are neural crest-derived tumors that arise from inherited or sporadic mutations in at least six independent genes: RET, VHL, NF1, and subunits B, C and D of succinate dehydrogenase (SDH). The proteins encoded by these multiple genes regulate distinct functions. To identify molecula...
ORGANISM(S): Homo sapiens 
2007-06-21 | E-GEOD-2841 | biostudies-arrayexpress
UnknownEvaluation of BGJ398, a Fibroblast Growth Factor Receptor 1-3 Kinase Inhibitor, in Patients With Advanced Solid Tumors Harboring Genetic Alterations in Fibroblast Growth Factor Receptors: Results of a Global Phase I, Dose-Escalation and Dose-Expansion Study.
Not available
S-EPMC6865065 | biostudies-literature
UnknownSynthetic gene circuits for cell state detection and protein tuning in human pluripotent stem cells
Not available
S-SCDT-10_15252-MSB_202110886 | biostudies-other
TranscriptomicsLong noncoding RNA expression in several hematopoietic progenitor and differentiated cell populations using a custom Agilent microarray
Mammals express thousands of long noncoding (lnc) RNAs, a few of which are shown to function in tissue development. However, the entire repertoire of lncRNAs and the extent to which they regulate biological processes in different tissues and species are not defined. Indeed, most lncRNAs are not cons...
ORGANISM(S): Mus musculus 
2014-02-20 | E-GEOD-51892 | biostudies-arrayexpress
TranscriptomicsIGR_MITF_STUDY_BBRB
A recent study of the characteristics of coexisting melanoma and renal cell carcinoma RCC in the same patients supports a genetic predisposition underlying the association between these two cancers. The microphthalmia associated transcription factor (MITF) was proposed to act as a melanoma oncogene;...
ORGANISM(S): Homo sapiens 
2011-09-03 | E-TABM-1198 | biostudies-arrayexpress
UnknownGlobal hospital-based disease management of acute diverticulitis: a prospective, international cohort study.
Not available
S-EPMC12512976 | biostudies-literature
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