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UnknownComparison of the Genomic Landscape Between Primary Breast Cancer in African American Versus White Women and the Association of Racial Differences With Tumor Recurrence.
Not available
S-EPMC4979243 | biostudies-literature
TranscriptomicsSIRT6 regulates glucose metabolism and glutamatergic synapse in the mouse retina
Microarray analysis on total retinal RNA from 15 day old Sirt6 wild-type (WT) and knock-out (KO) mice. The retina is one of the major energy consuming tissues within the body. In this context, synaptic transmission between light-excited rod photoreceptors and downstream ON-bipolar neurons is a highl...
ORGANISM(S): Mus musculus 
2014-07-30 | E-GEOD-56563 | biostudies-arrayexpress
TranscriptomicsSIRT6 suppresses pancreatic cancer through control of Lin28b
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-04-01 | E-GEOD-79505 | biostudies-arrayexpress
GenomicsSIRT6 suppresses pancreatic cancer through control of Lin28b [ChIP-seq]
Chromatin remodeling proteins are frequently dysregulated in human cancer, yet little is known about how they control tumorigenesis. Here, we uncover an epigenetic program mediated by the NAD+-dependent histone deacetylase Sirtuin 6 (SIRT6) that is critical for suppression of pancreatic ductal adeno...
ORGANISM(S): Mus musculus 
2016-04-01 | E-GEOD-79503 | biostudies-arrayexpress
TranscriptomicsPrimary human erythroid progenitor cells HDAC1 and HDAC2 shRNA knockdown samples
Gene expression profiling was performed on primary human erythroid progenitor cells expressing a control shRNA (luciferase), two different HDAC1 shRNAs, and two different HDAC2 shRNAs. The worldwide burden of sickle cell disease is enormous, with over 200,000 infants born with the disease each year ...
ORGANISM(S): Homo sapiens 
2010-07-29 | E-GEOD-22366 | biostudies-arrayexpress
TranscriptomicsPrimary human erythroid progenitor cells SAHA treatment samples
Gene expression profiling was performed on primary human erythroid progenitor cells left untreated or treated with 0.5uM SAHA. The worldwide burden of sickle cell disease is enormous, with over 200,000 infants born with the disease each year in Africa alone. Induction of fetal hemoglobin is a valida...
ORGANISM(S): Homo sapiens 
2010-07-29 | E-GEOD-22367 | biostudies-arrayexpress
TranscriptomicsGSK-3A and GSK-3B knockdown in AML cell lines
Gene expression data from AML cell lines, MOLM-14, U937, THP-1 and HL-60, that were infected with a scrambled control hairpin (shControl), two shRNAs directed against GSK-3B (shGSK3B_1 and shGSK3B_2), or two shRNAs directed against GSK-3A (shGSK3A_5 and shGSK3A_6). Acute myeloid leukemia (AML) is th...
ORGANISM(S): Homo sapiens 
2012-02-27 | E-GEOD-35200 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse inbred strains to identify germline cancer modifiers using parental strain expression mapping
Inherited genetic risk factors play an important role in cancer. However, other than cancer susceptibility genes found in familial cancer syndromes and inherited in a Mendelian fashion, little is known about modifier genes (germline variants that interact with each other and with environmental facto...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7270 | biostudies-arrayexpress
UnknownRandomized phase II study of carboplatin and paclitaxel with either linifanib or placebo for advanced nonsquamous non-small-cell lung cancer.
Not available
S-EPMC5478045 | biostudies-literature
TranscriptomicsMutant IDH inhibits HNF4a to disrupt hepatocyte differentiation and promote cholangiocarcinoma.
Gene expression of mouse hepatoblasts (HBs) expressing IDH1 WT, IDH1 R132C, IDH2 WT, R172K and empty vector controls (N=2 cultures for each condition) grown on collagen-coated plates and IDH1 R132C and empty vector controls on uncoated plates were evaluated using Affymetrix Mouse 430Av2 DNA microarr...
ORGANISM(S): Mus musculus 
2014-04-30 | E-GEOD-57002 | biostudies-arrayexpress
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