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MetabolomicsRA-MAP: mapping the molecular immunological landscape in early rheumatoid arthritis with vaccine controls

Rheumatoid arthritis (RA) is a chronic inflammatory disorder with poorly defined aetiology characterised by synovial inflammation with variable disease severity and drug responsiveness. To investigate the peripheral blood immune cell landscape of RA, we performed comprehensive clinical and molecu...

2021-06-16 | MTBLS1497 | MetaboLights
MetabolomicsMetabolic profiling of rheumatoid arthritis neutrophils reveals altered energy metabolism that is not affected by JAK inhibition
Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release of ROS and proteases directly causes damage to joints and tissues. Neutrophil function is directly affected by Janus Kinase (JAK) inhibitor drugs, including tofacitinib and baricitinib, which are clinically...
2023-07-11 | MTBLS4766 | MetaboLights
TranscriptomicsVitamin A nutritional status and retinoic acid as regulators of gene expression in rat liver
Vitamin A (retinol) is an essential precursor for the production of retinoic acid (RA), which in turn is a major regulator of gene expression, affecting cell differentiation throughout the body. Understanding how vitamin A nutritional status, as well as therapeutic retinoid treatment, regulates the ...
ORGANISM(S): Rattus norvegicus 
2011-08-31 | E-GEOD-24104 | biostudies-arrayexpress
UnknownThe impact of lifestyle modification on metabolic pathways in older adults with overweight/obesity and rheumatoid arthritis: a secondary exploratory analysis of the SWET-RA study.
Not available
S-EPMC12147280 | biostudies-literature
UnknownLiver-specific cytochrome P450 CYP2C22 is a direct target of retinoic acid and a retinoic acid-metabolizing enzyme in rat liver.
Not available
S-EPMC2882718 | biostudies-literature
UnknownDHRS3, a retinal reductase, is differentially regulated by retinoic acid and lipopolysaccharide-induced inflammation in THP-1 cells and rat liver.
Not available
S-EPMC3468555 | biostudies-literature
UnknownCYP26A1 gene promoter is a useful tool for reporting RAR-mediated retinoid activity.
Not available
S-EPMC6570419 | biostudies-literature
UnknownFrom Intention to Maintenance: A Two-Year Examination of Clinical and Lifestyle Changes in Rheumatoid Arthritis.
Not available
S-EPMC12717147 | biostudies-literature
UnknownHepatocyte Nuclear Factor 4α (HNF4α) Plays a Controlling Role in Expression of the Retinoic Acid Receptor β (RARβ) Gene in Hepatocytes.
Not available
S-EPMC10218549 | biostudies-literature
UnknownLipopolysaccharide opposes the induction of CYP26A1 and CYP26B1 gene expression by retinoic acid in the rat liver in vivo.
Not available
S-EPMC3843124 | biostudies-literature
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