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TranscriptomicsExpression and ChIP-seq analyses of embryonic stem cells, extraembryonic endoderm stem cells, and trophoblast stem cells
Bivalent histone domains have been proposed to contribute to pluripotency in embryonic stem cells, suggesting an epigenetic mechanism may regulate stem cell behavior in general. Here we compare histone modifications in two other stem cells derived from the blastocyst. We show that extraembryonic ste...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-15519 | biostudies-arrayexpress
TranscriptomicsEarly mouse embryo development
Expression profiling of mouse embryos at E2.5, E3.5, E4.25, E4.5, E5.5 E6.0 to identify genes regulated during development of the ICM (inner cell mass), TE (Trophectoderm) and PrE (Primative endoderm) Keywords: development dupicate analysis of time points
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-8339 | biostudies-arrayexpress
TranscriptomicsTrophoblast giant cell underrepresentation
This SuperSeries is composed of the SubSeries listed below. The BioProject ID on this superSeries record also encompasses a genome sequencing project under BioProject PRJNA213010. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-05-29 | E-GEOD-50585 | biostudies-arrayexpress
TranscriptomicsDifferentiation time course of trophoblast stem cells
To characterized the changes in gene expression during the differentiation of TS cells. TS cells can be derived from two time point during embryogenesis, cell lines tested were from each of these time points. Keywords: time course TS cells derived from either E3.5 or E6.5 embryos were differentiate...
ORGANISM(S): Mus musculus 
2010-02-21 | E-GEOD-12985 | biostudies-arrayexpress
TranscriptomicsExpression of Cdx2 or Gata3 in R1 mouse embryonic stem cells
To identify whether Cdx2 or Gata3 can activate trophoblast specific gene expression when expressed in R1 ES cells. To assess the dependency of Gata3 activity on Cdx2, Gata3 was also expressed in Cdx2-null ES cells. Keywords: gene expression a fusion construct of either Cdx2 or Gata3 and the tamoxif...
ORGANISM(S): Mus musculus 
2010-02-21 | E-GEOD-12986 | biostudies-arrayexpress
TranscriptomicsBMP and Activin treatment of mouse extraembryonic endoderm (XEN) cells
XEN cells are derived from the primitive endoderm of mouse blastocysts. In culture and in chimeras they exhibit properties of parietal endoderm. However, BMP signaling promotes XEN cells to form an epithelium and differentiate into visceral endoderm (VE). Of the several different subtypes of VE desc...
ORGANISM(S): Mus musculus 
2011-11-10 | E-GEOD-32199 | biostudies-arrayexpress
ProteomicsComparative analysis of the human and mouse placental transcriptome and proteome
An important question for the use of the mouse as a model for studying human disease is the degree of functional conservation of genetic control pathways from human to mouse. The human and mouse placenta show structural similarities but there have been no systematic attempt to assess their molecular...
ORGANISM(S): Mus musculus 
2009-06-29 | E-GEOD-13299 | biostudies-arrayexpress
TranscriptomicsHeparan Sulfation Dependent FGF Signalling Maintains ES Cells Primed for Differentiation in a Heterogeneous State
Embryonic stem (ES) cells continuously decide whether to maintain pluripotency or differentiate. While exogenous LIF and BMP4 perpetuate a pluripotent state, less is known about factors initiating differentiation. We show that heparan sulfate (HS) proteoglycans are critical co-receptors for signals ...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-15974 | biostudies-arrayexpress
Proteomics,MultiomicsPSE115_PSM1063_mouse
Placentas from naturally-mated crosses of C57Bl/6J mice on embryonic day 17.5 were cut into thick slices. A scalpel blade was used to isolate the blood-red labyrin th tissue from the more poorly vascularized, and hence paler, spongiotrophoblast tissue, and to remove the superficial chorionic vascula...
ORGANISM(S): Mus Musculus 
2009-12-31 | PAe001560 | PeptideAtlas
ProteomicsM.musculus - Kidney, Protein peptide count (Kislinger,cell,2006)
abundance based on Protein peptide count, Interaction consistency score: 1.8, Coverage: 6
ORGANISM(S): 10090 
2006-00-00 | 2752498147 | PAXDB
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