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MetabolomicsHif1α-Dependent Uncoupling Of Glycolysis Suppresses Tumor Cell Proliferation
Hypoxia-inducible factor-1α (HIF1α) attenuates mitochondrial activity while promoting glycolysis. Paradoxically, it remains unknown why lower glycolysis is compromised in human clear cell renal cell carcinomas (ccRCC), in which HIF1α acts a tumor suppressor by inhibiting cell autonomous proliferatio...
2024-03-15 | MTBLS8901 | MetaboLights
UnknownBurkitt's lymphoma in pregnant woman: Difficult management of a rare case.
Not available
S-EPMC7876741 | biostudies-literature
MetabolomicsRare and common genetic determinants of metabolic individuality and their effects on human health (EPIC-Norfolk study assays)

Garrod’s concept of “chemical individuality” has contributed to comprehension of the molecular origins of human diseases. Untargeted high-throughput metabolomic technologies provide an in-depth snapshot of human metabolism at scale. We studied the genetic architecture of the human plasma metabolo...

2022-09-09 | MTBLS833 | MetaboLights
TranscriptomicsTranscriptomic analysis of fresh frozen clear-cell renal cell carcinoma tissues treated with VEGFR-TKIs in first line
Transcriptomic analysis using qRT-PCR was performed on fresh frozen clear-cell renal cell carcinoma tissues treated with VEGFR-TKIs in first line (n=109). The transcriptomic data from this experiment were analyzed together with miRNA sequencing data from FFPE samples from the same tumor (E-MTAB-1058...
ORGANISM(S): Homo sapiens 
2021-06-07 | E-MTAB-10592 | biostudies-arrayexpress
UnknownSARS-CoV2 infection impairs the metabolism and redox function of cellular glutathione.
Not available
S-EPMC8190457 | biostudies-literature
TranscriptomicsMicroRNA sequencing of clear-cell renal cell carcinoma tissues (FFPE) treated with VEGFR-TKIs in first line.
We investigated tumoral miRNA expression of patients with clear-cell renal cell carcinoma treated with VEGFR-TKIs in first line. Sequencing was performed on 109 FFPE resection specimens. The samples were sequenced in 2 major batches (2014 and 2017).
ORGANISM(S): Homo sapiens 
2021-06-07 | E-MTAB-10586 | biostudies-arrayexpress
UnknownPattern of comorbidities and 1-year mortality in elderly patients with COPD hospitalized in internal medicine wards: data from the RePoSI Registry.
Not available
S-EPMC7384278 | biostudies-literature
UnknownChronic myeloid leukemia management at the time of the COVID-19 pandemic in Italy. A campus CML survey.
Not available
S-EPMC7301058 | biostudies-literature
UnknownClinical-Genetic Features Influencing Disability in Spastic Paraplegia Type 4: A Cross-sectional Study by the Italian DAISY Network.
Not available
S-EPMC8969300 | biostudies-literature
UnknownItalian patients with hemoglobinopathies exhibit a 5-fold increase in age-standardized lethality due to SARS-CoV-2 infection.
Not available
S-EPMC9011434 | biostudies-literature
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