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TranscriptomicsTranscription profiling by array of human bone marrow hematopoietic stem cells from healthy young and elderly individuals
In the human hematopoietic system, aging is associated with decreased bone marrow cellularity, decreased adaptive immune system function, and increased incidence of anemia and other hematological disorders and malignancies. Recent studies in mice suggest that changes within the hematopoietic stem ce...
ORGANISM(S): Homo sapiens 
2011-11-11 | E-GEOD-32719 | biostudies-arrayexpress
TranscriptomicsHighly efficient reprogramming to pluripotency and directed differentiation using synthetic mRNA
Clinical application of induced pluripotent stem (iPS) cells is limited by low efficiency of iPS derivation, and protocols that permanently modify the genome to effect cellular reprogramming. Moreover, safe and effective means of directing the fate of patient-specific iPS cells towards clinically us...
ORGANISM(S): Homo sapiens 
2010-09-30 | E-GEOD-23583 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of long-term hematopoietic stem cells from old and young mice to investigate the mechanisms of hematopoietic aging
Loss of immune function and an increased incidence of myeloid leukemia are two of the most clinically significant consequences of aging of the hematopoietic system. To better understand the mechanisms underlying hematopoietic aging, we evaluated the cell intrinsic functional and molecular properties...
ORGANISM(S): Mus musculus 
2007-12-19 | E-GEOD-4332 | biostudies-arrayexpress
TranscriptomicsDNA methylation dynamics during in vivo differentiation of blood and skin stem cells
DNA methylation is a mechanism of epigenetic regulation that is common to all vertebrates. Functional studies support its relevance for tissue homeostasis, but the global dynamics of DNA methylation during in vivo differentiation have not been worked out in detail. Here we report high-resolution DNA...
ORGANISM(S): Mus musculus 
2012-07-14 | E-GEOD-38557 | biostudies-arrayexpress
TranscriptomicsIncomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells
Human induced pluripotent stem (iPS) cells are remarkably similar to embryonic stem (ES) cells, but recent reports indicate that there may be important differences between them. We carried out a systematic comparison of human iPS cells generated from hepatocytes (representative of endoderm), skin fi...
ORGANISM(S): Homo sapiens 
2011-04-17 | E-GEOD-23034 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse heart from cardiac-specific conditional knockout deletion of menage-a-trios-1 (MAT1)
The Cdk7/cyclin H/menage-a-trois 1 (MAT1) heterotrimer has proposed functions in transcription as the kinase component of basal transcription factor TFIIH and is activated in adult hearts by hypertrophic pathways. Using cardiac-specific Cre, we ablated MAT1 in myocardium. Despite reduced Cdk7 activi...
ORGANISM(S): Mus musculus 
2009-04-23 | E-GEOD-6662 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse multipotent adult progenitor cells (MAPCs), 2 different clones
We compare the transcriptome of two different clones of multipotent adult progenitor cells (MAPCs) using Affymetrix arrays. Experiment Overall Design: Three mRNA samples (biological replicates) per cell type taken at different passage number were compared. Two independently isolated MAPC clones were...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6291 | biostudies-arrayexpress
UnknownSafety, uptake, and use of a dapivirine vaginal ring for HIV-1 prevention in African women (HOPE): an open-label, extension study.
Not available
S-EPMC8038210 | biostudies-literature
UnknownUse of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women.
Not available
S-EPMC4993693 | biostudies-literature
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