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The act of surgery strongly stimulated breast cancer cell growth in mice. Local irradiation of wounded breast efficiently prevented wounded-induced breast cancer cell growth. These modifications were linked to miR modulation both in human specimens and in the mouse model, in vivo. The most significa...
ORGANISM(S): Homo sapiens 
mRNA profiles of thousands of human tumors are available, but methods to deduce oncogenic signaling networks from these data lag behind. It is especially challenging to identify main-regulatory routes, and to generalize conclusions obtained from experimental models. We designed the bioinformatic pla...
ORGANISM(S): Homo sapiens 
The majority of neuroblastoma patients have tumors that initially respond to chemotherapy, but a large proportion of patients will experience therapy-resistant relapses. The molecular basis of this aggressive phenotype is unknown. Whole genome sequencing of 23 paired diagnostic and relapsed neurobla...
Data Access Committee EGAC00001000321
The majority of neuroblastoma patients have tumors that initially respond to chemotherapy, but a large proportion of patients will experience therapy-resistant relapses. The molecular basis of this aggressive phenotype is unknown. Whole genome sequencing of 23 paired diagnostic and relapsed neurobla...
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