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MetabolomicsMetabolic profiling of ob/ob mouse fatty liver using HR-MAS 1H-NMR combined with gene expression analysis reveals alterations in betaine metabolism and the transsulfuration pathway
Metabolic perturbations resulting from excessive hepatic fat accumulation are poorly understood. Thus, in this study, leptin-deficient ob/ob mice, a mouse model of fatty liver disease, were used to investigate metabolic alterations in more detail. Metabolites were quantified in intact liver tissues ...
2018-01-31 | MTBLS400 | MetaboLights
ProteomicsCharacterization of cerebrospinal fluid via data-independent acquisition mass spectrometry
Cerebrospinal fluid (CSF) is in direct contact with the brain and serves as a valuable specimen to examine diseases of the central nervous system through analyzing its components. These include the analysis of metabolites, cells as well as proteins. For identifying new suitable diagnostic protein bi...
ORGANISM(S): Homo sapiens (Human) 
2018-09-17 | PXD010690 | Pride
Cerebrospinal fluid Dia Proteomics Data-independent acquisition mass spectrometry Csf Spectral library 
ProteomicsCharacterization of cerebrospinal fluid via data-independent acquisition mass spectrometry
Cerebrospinal fluid (CSF) is in direct contact with the brain and serves as a valuable specimen to examine neurodegenerative diseases in order to identify suitable diagnostic biomarkers. In the field of neuroproteomics the most popular mass spectrometry-based strategy for biomarker discovery studies...
ORGANISM(S): Homo sapiens (Human) 
2018-09-17 | PXD009624 | Pride
Cerebrospinal fluid Lc-ms Spectral library Data-independent acquisition 
ProteomicsCharacterization of cerebrospinal fluid via data-independent acquisition mass spectrometry
Cerebrospinal fluid (CSF) is in direct contact with the brain and serves as a valuable specimen to examine neurodegenerative diseases in order to identify suitable diagnostic biomarkers. In the field of neuroproteomics the most popular mass spectrometry-based strategy for biomarker discovery studies...
ORGANISM(S): Homo sapiens (Human) 
2019-02-14 | PXD009623 | Pride
Cerebrospinal fluid Lc-ms Spectral library Data-independent acquisition 
ProteomicsDYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer
Highly malignant pancreatic ductal adenocarcinoma (PDAC) is characterized by an abundant immunosuppressive and fibrotic tumor microenvironment (TME). Future therapeutic attempts therefore demand targeting of both compartments in order to be effective. We show here that Dual Specificity and Tyrosine...
ORGANISM(S): Mus Musculus 
2024-01-02 | MSV000093747 | MassIVE
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