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ProteomicsA proteomics approach to profiling the temporal translational response to stress and growth
One major knowledge gap in systems biology is the quantification of dynamic protein synthesis rates in response to cell perturbation. To address this gap, we have developed MITNCAT, multiplex isotope tagging / non-canonical amino acid tagging, a novel method enabling the robust quantification of pr...
ORGANISM(S): Homo sapiens (Human) 
2018-12-04 | PXD009592 | Pride
Synthesis Translation Translatome 
TranscriptomicsA genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers
In a genome-wide screen of human cancer cell lines, we identified homozygous intragenic microdeletions involving genes encoding components of the apical-basal cell polarity complexes. Among these, PARD3 is disrupted in cell lines and primary tumors from squamous carcinomas and glioblastomas. Reco...
ORGANISM(S): Homo sapiens 
2011-11-03 | E-GEOD-20306 | biostudies-arrayexpress
ProteomicsEarly Signaling Dynamics of EGFR
Despite extensive study of the epidermal growth factor receptor (EGFR) signaling network, the immediate post-translational changes that occur in response to growth factor stimulation remain poorly characterized; as a result, the biological mechanisms underlying signaling initiation remain obscured. ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080800 | MassIVE
ProteomicsDefining HLA-II ligand processing and binding rules with mass spectrometry enhances cancer epitope prediction
Increasing evidence indicates CD4+ T cells can recognize cancer-specific antigens and control tumor growth. However, it remains difficult to predict the antigens that will be presented by human leukocyte antigen class II molecules (HLA-II) - hindering efforts to optimally target them therapeutically...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-18 | MSV000083991 | MassIVE
UnknownEfficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico.
Not available
S-EPMC8693692 | biostudies-literature
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