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ProteomicsChemical translatome analysis in AML cells treated with different drug combinations
Our prior research has shown that AML with FLT3-ITD is particularly susceptible to the combination of FLT3 inhibitors and protein synthesis inhibitors when compared to FLT3-WT. In this study, we employed a click chemistry-based approach to quantify the alterations in the translatome under FLT3 inhib...
ORGANISM(S): Homo sapiens (Human) 
2024-03-26 | PXD047567 | Pride
Translatome Aml 
ProteomicsTranslatome analyses by bio-orthogonal non-canonical amino acid labeling reveal that MR1-activated MAIT cells induce an M1 phenotype and antiviral programming in antigen-presenting monocytes_bicellular1
MAIT cells are multifunctional innate-like effector cells recognizing bacterial-derived vitamin B metabolites presented by the non-polymorphic MHC class I related-1 molecule (MR1). Activated MAIT cells can exert regulatory, pro-inflammatory, or cytotoxic responses that enable the direct killing of i...
ORGANISM(S): Homo sapiens (Human) 
2023-02-08 | PXD039785 | Pride
Boncat Mait cell Antiviral Translatome Mr1-mediated mait cell activation M1 macrophage polarization Proteomics 
ProteomicsTranslatome analyses by bio-orthogonal non-canonical amino acid labeling reveal that MR1-activated MAIT cells induce an M1 phenotype and antiviral programming in antigen-presenting monocytes_bicellular2
MAIT cells are multifunctional innate-like effector cells recognizing bacterial-derived vitamin B metabolites presented by the non-polymorphic MHC class I related-1 molecule (MR1). Activated MAIT cells can exert regulatory, pro-inflammatory, or cytotoxic responses that enable the direct killing of i...
ORGANISM(S): Homo sapiens (Human) 
2023-02-08 | PXD039804 | Pride
Boncat Mait cell Antiviral Translatome Mr1-mediated mait cell activation M1 macrophage polarization Proteomics 
ProteomicsTranslatome analyses by bio-orthogonal non-canonical amino acid labeling reveal that MR1-activated MAIT cells induce an M1 phenotype and antiviral programming in antigen-presenting monocytes_monocellular
MAIT cells are multifunctional innate-like effector cells recognizing bacterial-derived vitamin B metabolites presented by the non-polymorphic MHC class I related-1 molecule (MR1). Activated MAIT cells can exert regulatory, pro-inflammatory, or cytotoxic responses that enable the direct killing of i...
ORGANISM(S): Homo sapiens (Human) 
2023-02-08 | PXD039820 | Pride
Boncat Mait cell Antiviral Translatome Mr1-mediated mait cell activation M1 macrophage polarization Proteomics 
ProteomicsProteomic analysis of senescent translatome
To examine senescent translatome, we combined L-azidohomoalanine (AHA)-mediated labeling of newly synthesized proteins followed by click chemistry for biotin conjugation with the DiDBiT in proliferating and senescent cells. Senescence was induced using a stress-induced senescence model (bleomycin-in...
ORGANISM(S): Homo sapiens (Human) 
2024-10-04 | PXD054317 | Pride
Senescence Translation 
ProteomicsTranslatome analyses by bio-orthogonal non-canonical amino acid labeling reveal that MR1-activated MAIT cells induce an M1 phenotype and antiviral programming in antigen-presenting monocytes_bicellular 3
MAIT cells are multifunctional innate-like effector cells recognizing bacterial-derived vitamin B metabolites presented by the non-polymorphic MHC class I related-1 molecule (MR1). Activated MAIT cells can exert regulatory, pro-inflammatory, or cytotoxic responses that enable the direct killing of i...
ORGANISM(S): Homo sapiens (Human) 
2023-02-08 | PXD039810 | Pride
Boncat Mait cell Antiviral Translatome Mr1-mediated mait cell activation M1 macrophage polarization Proteomics 
GenomicsPolysome profiling of Arabidopsis translatome upon hypertonic stress
Polysome profiling of Arabidopsis translatome upon hypertonic stress
PRJNA798023 | ENA
GenomicsTranslatome profiling of nodule invasion zone
Translatome profiling followed by RNA sequencing
PRJEB72304 | ENA
ProteomicsFunctional translatome proteomics reveal converging regulation by mTORC1 and eIF2α
Regulation of the translatome is essential during stress. However, the precise sets of translational targets regulated by the key translational stress responses –integrated stress response (ISR) and mTORC1 – remain elusive. We developed multiplexed enhanced protein dynamics (mePROD) proteomics, comb...
ORGANISM(S): Homo sapiens (Human) 
2019-12-06 | PXD014377 | Pride
Human Tmt Translation Pulsed silac 
ProteomicsProteome and Translatome of SARS-CoV-2 infected cells
Cells were infected with SARS-CoV-2 and profiled for translatome and proteome after 2,6,10 and 24 hours
ORGANISM(S): Homo sapiens (Human) 
2020-07-20 | PXD017710 | Pride
Sars-cov-2 Proteome Translatome 
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