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TranscriptomicsGenetic and transcriptome analyses of early T-cell checkpoint failure and leukemia initiation in Rag1-deficient NOD mice
Both immunodeficient and wild type NOD mice exhibit defects in control of early T-cell development in the thymus. We show that Rag1-deficient NOD mice fail to enforce both the b-selection checkpoint and an earlier T-cell commitment checkpoint, based on genome-wide genetic and transcriptome analyses....
ORGANISM(S): Mus musculus 
2013-03-07 | E-GEOD-40688 | biostudies-arrayexpress
TranscriptomicsTranscriptome impact of acute deletion of Gata3 in murine pro-T cells
The purpose of the study was to determine what genes in DN2 pro-T cells are immediately regulated by the transcription factor GATA-3, either as activation targets or as repression targets. To do this, two pairs of Gata3-floxed and control pro-T cells were generated and analyzed by RNA-seq within th...
ORGANISM(S): Mus musculus 
2014-09-02 | E-GEOD-59215 | biostudies-arrayexpress
TranscriptomicsDynamic Transformations of Genome-wide Epigenetic Marking and Transcriptional Control Establish T Cell Identity [RNA-Seq]
T cell development comprises a stepwise process of commitment from a multipotent precursor. To define molecular mechanisms controlling this progression, we probed five stages spanning the commitment process using deep sequencing RNA-seq and ChIP-seq methods to track genome-wide shifts in transcripti...
ORGANISM(S): Mus musculus 
2012-04-13 | E-GEOD-31234 | biostudies-arrayexpress
GenomicsDynamic Transformations of Genome-wide Epigenetic Marking and Transcriptional Control Establish T Cell Identity [ChIP-Seq]
T cell development comprises a stepwise process of commitment from a multipotent precursor. To define molecular mechanisms controlling this progression, we probed five stages spanning the commitment process using deep sequencing RNA-seq and ChIP-seq methods to track genome-wide shifts in transcripti...
ORGANISM(S): Mus musculus 
2012-04-13 | E-GEOD-31233 | biostudies-arrayexpress
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