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TranscriptomicsEffect of Ribavirin on Viral Kinetics and Liver Gene Expression in Chronic Hepatitis C
Background/Aims: Ribavirin improves treatment response to pegylated-interferon (PEG-IFN) in chronic hepatitis C but the mechanism remains controversial. We studied correlates of response and mechanism of action of ribavirin in treatment of hepatitis C. Methods: 70 treatment-naïve patients were rand...
ORGANISM(S): Homo sapiens 
2013-03-08 | E-GEOD-38663 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of primary human hepatocytes derived from hepatitis C patients treated with type III interferons (IFNs) for 6 or 24 hours
Recent identification of IL28B gene polymorphisms associated with hepatitis C virus (HCV) clearance suggests a role for type III interferons (IFNs) in hepatitis C infection. The function of type III IFNs in intrinsic antiviral immunity is poorly understood. Here we show that HCV infection of primar...
ORGANISM(S): Homo sapiens 
2012-03-09 | E-GEOD-31193 | biostudies-arrayexpress
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