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ProteomicsProteogenomic analysis of Human acute myeloid leukemia
Here, we used OpenCustomDB, a web-based tool that uses both sample-specific RNAseq data to identify genomic variants and the OpenProt resource that annotates alternative proteins in addition to canonical proteins. We tested OpenCustomDB with a cohort of 17 patients with acute myeloid leukemia and de...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD029240 | Pride
Proteogenomics Human Altprot Aml 
ProteomicsFirst evidence that a protein coded by a short ORF, not by the annotated CDS is the main gene product
Proteogenomics and ribosome profiling concurrently show that genes may code for both a large and one or more small proteins translated from annotated coding sequences (CDSs) and unannotated alternative open reading frames (named alternative ORFs or altORFs), respectively, but the stoichiometry betwe...
ORGANISM(S): Homo sapiens (Human) 
2018-11-21 | PXD008147 | Pride
Crispr-cas9 Short orf Targeted proteomics Translation 
ProteomicsAltFUS interactome from mitochondrial extracts
Novel functional coding sequences (altORFs) are camouflaged within annotated ones (CDS) in a different reading frame. We discovered an altORF nested in the FUS CDS encoding a conserved 170 amino acid protein, altFUS. AltFUS is endogenously expressed in human tissues, notably in the motor cortex and ...
ORGANISM(S): Homo sapiens (Human) 
2020-10-12 | PXD021320 | Pride
Alternative protein Altfus 
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