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TranscriptomicsGenome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo
We present an approach for globally monitoring RNA structure in native conditions in vivo with single nucleotide precision. This method is based on in vivo modification with dimethyl sulfate (DMS), which reacts with unpaired adenine and cytosine residues9, followed by deep sequencing to monitor modi...
ORGANISM(S): Homo sapiens 
2013-12-15 | E-GEOD-45803 | biostudies-arrayexpress
TranscriptomicsThe ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments
Recent studies highlight the importance of translational control in determining protein abundance, underscoring the value of measuring gene expression at the level of translation. We present a protocol for genome-wide, quantitative analysis of in vivo translation by deep sequencing. This ribosome pr...
ORGANISM(S): Homo sapiens 
2012-07-26 | E-GEOD-37744 | biostudies-arrayexpress
UnknownTelomerase RNA structural heterogeneity in living human cells detected by DMS-MaPseq.
Not available
S-EPMC11754830 | biostudies-literature
TranscriptomicsCausal signals between codon bias, mRNA structure and the efficiency of translation and elongation
Ribosome profiling data reports on the distribution of translating ribosomes, at steady-state, with codon-level resolution. We present a robust method to extract codon translation rates and protein synthesis rates from these data, and identify causal features associated with elongation and translati...
ORGANISM(S): Saccharomyces cerevisiae 
2015-01-05 | E-GEOD-63789 | biostudies-arrayexpress
TranscriptomicsPediatric RTIs
This series includes 278 microarrays used to detect respiratory viruses in a set of nasopharyngeal lavage specimens from children with respiratory tract infections Objective: To assess the utility of a pan-viral DNA microarray platform (Virochip) in the detection of viruses associated with pediatri...
ORGANISM(S): Viruses 
2010-05-26 | E-GEOD-10294 | biostudies-arrayexpress
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