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GenomicsH3K4me3 modification profiling of Huntingtons disease and control human post-mortem prefrontal cortex brain samples
Huntington’s disease (HD) is an autosomal-dominant neurodegenerative disorder resulting from expansion in the number of CAG repeats in the coding region of exon 1 of the Huntingtin (HTT) gene. One of the most widely studied chromatin modifications is trimethylated lysine 4 of histone 3 (H3K4me3). ...
ORGANISM(S): Homo sapiens 
2015-12-14 | E-GEOD-68952 | biostudies-arrayexpress
GenomicsA role for non-coding variation in schizophrenia
A large portion of common variant loci associated with genetic risk for schizophrenia reside within non-coding sequence of unknown function. Here, we demonstrate promoter and enhancer enrichment in schizophrenia variants associated with expression quantitative trait loci (eQTL). The enrichment is gr...
ORGANISM(S): Homo sapiens 
2014-10-17 | E-GEOD-62391 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer's disease
Recent work has identified roles for environmental, genetic and epigenetic factors in AD risk. Motivated by suspected roles for epigenetic modifications in AD, we performed a genome-wide screen of DNA methylation using the Illumina Infinium HumanMethylation450 array platform on bulk tissue samples f...
ORGANISM(S): Homo sapiens 
2015-12-18 | E-GEOD-76105 | biostudies-arrayexpress
TranscriptomicsMolecular Signatures Underlying Selective Regional Vulnerability to Alzheimer's Disease
Alzheimer's disease (AD) is the most common form of dementia, characterized by progressive cognitive impairment and neurodegeneration as a result of abnormal neuronal loss. To elucidate the molecular systems associated with AD, we characterized the gene expression changes associated with multiple cl...
ORGANISM(S): Homo sapiens 
2016-08-19 | E-GEOD-84422 | biostudies-arrayexpress
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