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TranscriptomicsMulti-region copy-number analysis
Intra-tumour heterogeneity (ITH) foster tumour adaptation and hamper the efficiency of personalised medicine approaches. We investigated the extent of ITH within individual clear cell renal cell carcinomas (ccRCC) by multi-region sampling and copy number analysis. We analyzed 63 tumour regions and 8...
ORGANISM(S): Homo sapiens 
2013-06-04 | E-GEOD-47077 | biostudies-arrayexpress
TranscriptomicsTranscription profiling validation of an custom mouse oligo array using liver samples following treatment with the hepatotoxin phenobarbital and variable hybridization protocols
The use of custom-made focused microarrays has become a popular alternative, allowing the study of genes relevant to a specific hypothesis. To address the limitations of commercial arrays in toxicogenomics investigations, we have developed a custom mouse oligonucleotide microarray, the HC ToxArrayTM...
ORGANISM(S): Mus musculus 
2006-10-30 | E-MEXP-525 | biostudies-arrayexpress
TranscriptomicsEffects of pulp and paper mill effluents on gene expression in the fathead minnow hypothalamus
We evaluated the possible mechanisms by which exposures to pulp and paper mill effluents gene expression in the fathead minnow hypothalamus Keywords: Toxicology Sexually mature fathead minnows were exposed to 100% pulp and paper mill effluents for 5 days. Tanks contained 4 females and 2 males. A ...
ORGANISM(S): Pimephales promelas 
2010-07-07 | E-GEOD-17130 | biostudies-arrayexpress
UnknownCross-sectional analysis of plasma and CSF metabolomic markers in Huntington's disease for participants of varying functional disability: a pilot study.
Not available
S-EPMC7686309 | biostudies-literature
UnknownAn exploratory metabolomic comparison of participants with fast or absent functional progression from 2CARE, a randomized, double-blind clinical trial in Huntington's disease.
Not available
S-EPMC10784537 | biostudies-literature
TranscriptomicsExpression data from different samples of a single ccRCC patient.
We have sampled several tumour regions from a single patient before and after everolimus treatment, including both primary and metastatic site samples to investigate intra-tumour heterogeneity. We selected 4 primary tumour regions, including a pre-treatment biopsy, and 1 metastatic region for expres...
ORGANISM(S): Homo sapiens 
2011-08-05 | E-GEOD-31232 | biostudies-arrayexpress
ModelsHui2016 - Age-related changes in articular cartilage
Hui2014 - Age-related changes in articular cartilage This model is described in the article: Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage Wang Hui1, David A Young1, Andrew D Rowan1, Xin Xu2, Tim E Cawston1, Ca...
2024-09-02 | BIOMD0000000560 | BioModels
TranscriptomicsThe effect of bisphenol A on human preadipocyte differentiation.
Background: Exposure to the endocrine-disrupting chemical bisphenol A (BPA) is correlated with obesity and promotes adipogenesis of human preadipocytes into mature adipocytes. However, the mechanism of action of BPA-induced human adipogenesis in vitro remains to be fully characterized. Methods: In t...
ORGANISM(S): Homo sapiens 
2014-04-15 | E-GEOD-56085 | biostudies-arrayexpress
UnknownRisk factors for suicidality in Huntington disease: An analysis of the 2CARE clinical trial.
Not available
S-EPMC6448454 | biostudies-literature
TranscriptomicsLack of hepatic response of microRNA in mice following DB[a,h]A exposure (Agilent miRNA)
Dibenzo[a,h]anthracene DB[a,h]A is a polycyclic aromatic hydrocarbon potent carcinogen. Few studies have investigated the role of DB[a,h]A on mRNA and miRNA expression. In this study a 10-week old male MutaTM Mouse were exposed to 6.25, 12.5, and 25 mg/kg/day DB[a,h]A by oral gavage for 28 cons...
ORGANISM(S): Mus musculus 
2013-07-02 | E-GEOD-35195 | biostudies-arrayexpress
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