Rowley David D - OmicsDI

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Lab affiliation

University of Melbourne, Melbourne, Australia (1)

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Integrated multi-omics for rapid rare disease diagnosis on a national scale

The Australian Acute Care Genomics program provides ultra-rapid diagnostic testing to critically ill infants and children with suspected genetic conditions. Over two years, we performed whole genome sequencing (WGS) in 290 families, with average time to result of 2.9 days, and diagnostic yield of 47...

ORGANISM(S): Homo sapiens (Human)

2023-10-24 | PXD042001 | Pride

Cells Comprising the Prostate Cancer Microenvironment Lack Recurrent Clonal Somatic Genomic Aberrations

Prostate cancer-associated stroma (CAS) plays an active role in malignant transformation, tumor progression, and metastasis. Molecular analyses of CAS have demonstrated significant changes in gene expression; however, conflicting evidence exists on whether genomic alterations in benign cells compris...

ORGANISM(S): Homo sapiens

2016-02-12 | E-GEOD-76456 | biostudies-arrayexpress

Gene expression profiles (stroma and epithelium) of prostate cancer mouse models (JOCK1, Pro-Cat M-CM-^W JOCK1, Ubi-Cat M-CM-^W JOCK1)

The fibroblast growth factor receptor (FGFR) and canonical Wnt signaling pathways are important regulators of carcinogenesis; however, the interaction between these two pathways in the context of prostate cancer (PCa) has not been fully elucidated. Using novel transgenic mouse models, we describe Wn...

ORGANISM(S): Mus musculus

2014-01-07 | E-GEOD-41344 | biostudies-arrayexpress

Identification of SOX3 as an XX male sex reversal gene in mice and humans.

Not available

S-EPMC3007141 | biostudies-literature

Results of the two incidence screenings in the National Lung Screening Trial.

Not available

S-EPMC4307922 | biostudies-literature

No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing.

Not available

S-EPMC4938802 | biostudies-literature

Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19: The RECOVERY-RS Randomized Clinical Trial.