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TranscriptomicsTranscription profiling of wild type and Rpe65-/- mouce retinae to characterize gene response in Rpe65-/- mouse model of Lebers congenital amaurosis during progression of the disease.
To characterize gene response in RPE65-/- mouse model of Leber's congenital amaurosis during progression of the disease, we analyzed differential gene expression in retinae early in the development of the disease, namely before and at the onset of photoreceptor cell death in knock-out mice of 2, 4 a...
ORGANISM(S): Mus musculus 
2007-09-07 | E-GEOD-3249 | biostudies-arrayexpress
TranscriptomicsA combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models [scRNA-seq: Rpe65-KO]
To determine the gene expression changes in the retina P57-P60 Rpe65-/- mice , we collected retina samples from Rpe65-/- and WT (C57BL/6J mice) mice, generated single-cell suspensions, and performed scRNA-Seq (10X Genomics). One group of Rpe65-/- mice was treated for 5 weeks via dietary administrati...
ORGANISM(S): Mus musculus 
2024-06-06 | GSE263877 | GEO
GenomicsA combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models [scRNA-seq: Rpe65-KO]
A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models [scRNA-seq: Rpe65-KO]
PRJNA1099665 | ENA
TranscriptomicsAnalysis of RPE65 loss of function in mouse retina
To characterize gene response in RPE65-/- mouse model of Leber’s congenital amaurosis during progression of the disease, we analyzed differential gene expression in retinae early in the development of the disease, namely before and at the onset of photoreceptor cell death in knock-out mice of 2, 4 a...
ORGANISM(S): Mus musculus 
2006-02-01 | GSE3249 | GEO
UnknownRPE65 Variant p.(E519K) Causes a Novel Dominant Adult-Onset Maculopathy in 83 Affected Individuals.
Not available
S-EPMC12468096 | biostudies-literature
UnknownRPE65 Palmitoylation: A Tale of Lipid Posttranslational Modification.
Not available
S-EPMC9351226 | biostudies-literature
UnknownRPE65 is the isomerohydrolase in the retinoid visual cycle.
Not available
S-EPMC1194921 | biostudies-literature
GenomicsA combination treatment based on drug repurposing demonstrates mutation agnostic efficacy in pre-clinical retinopathy models. [RNA-seq: RPE65-KO]
A combination treatment based on drug repurposing demonstrates mutation agnostic efficacy in pre-clinical retinopathy models. [RNA-seq: RPE65-KO]
PRJNA998380 | ENA
UnknownHuman cone photoreceptor dependence on RPE65 isomerase.
Not available
S-EPMC1986623 | biostudies-literature
UnknownLentiviral mediated RPE65 gene transfer in healthy hiPSCs-derived retinal pigment epithelial cells markedly increased RPE65 mRNA, but modestly protein level.
Not available
S-EPMC7264209 | biostudies-literature
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