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Translational control by RPL22L1-specific ribosomes enhances DNA repair and chemoresistance
Glioblastoma (GBM) is characterized by an exceptionally high intratumoral heterogeneity. However, the molecular mechanisms underlying the origin of different GBM cell populations remain unclear. Here we found that the composition of ribosomes of GBM cells in the tumor core and edge differ due to alt...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD035849 | Pride
Ribosome heterogeneity has emerged as a regulatory layer in gene expression, yet its biological roles in cancers remain poorly characterized. Here, we identify RPL22L1, a paralog of the ribosomal protein RPL22, as a key modulator of DNA damage response (DDR) in colorectal cancer cells. DNA damage in...
ORGANISM(S): Homo sapiens 
2026-06-21 | GSE310281 | GEO
Glioblastoma (GBM) is characterized by an exceptionally high intratumoral heterogeneity. However, the molecular mechanisms underlying the origin of different GBM cell populations remain unclear. Here we found that the composition of ribosomes of GBM cells in the tumor core and edge differ due to alt...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD035767 | Pride
RNA-seq analysis of parent, RPL22L1 knockout and RPL22 reconstituted HCT116 cells.
Interactome of different isoforms of RPL22L1 protein in human glioblastoma cells
RNA-Seq analysis of Rpl22l1-deficient murine CD4-CD-CD44-CD25+ (DN3) thymocytes
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