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TranscriptomicsChIP-chip data of HA-Yra1 and Rrm3-Flag in wild-type and cells overexpressing YRA1
Transcription is a major obstacle for replication fork progression and a cause of genome instability. Yra1 is an essential nuclear factor of the evolutionarily conserved family of hnRNP-like export factors that when overexpressed impairs mRNA export and cell growth. Through this ChIP-chip analysis i...
ORGANISM(S): Saccharomyces cerevisiae 
2016-03-11 | E-GEOD-68486 | biostudies-arrayexpress
TranscriptomicsMapping Replication Fork Pause Sites in S. cerevisiae
Replication forks face multiple obstacles that slow their progression. By two-dimensional gel analysis, yeast forks pause at stable DNA protein complexes, and this pausing is greatly increased in the absence of the Rrm3 helicase. We used a genome wide approach to identify 96 sites of very high DNA p...
ORGANISM(S): Saccharomyces cerevisiae 
2009-06-15 | E-GEOD-16218 | biostudies-arrayexpress
TranscriptomicsRad53-mediated regulation of Rrm3 and Pif1 DNA helicases contributes to prevention of aberrant fork transitions under replication stress.
Replication stress activates the Mec1ATR and Rad53 kinases. Rad53 phosphorylates nuclear pores to counteract gene gating, thus preventing aberrant transitions at forks approaching transcribed genes. Here, we show that Rrm3 and Pif1, DNA helicases assisting fork progression across pausing sites, are ...
ORGANISM(S): Saccharomyces cerevisiae 
2015-09-24 | E-GEOD-68214 | biostudies-arrayexpress
TranscriptomicsChIP-chip data of Rrm3-Flag in wild-type and rpb1-1 cells
Transcription is a major contributor to genome instability.A main cause of transcription-associated instability relies on the capacity of transcription to stall replication. Such genome instability is increased in RNAPII mutants. ChIP-chips performed in asynchronous cultures showed an increase of th...
ORGANISM(S): Saccharomyces cerevisiae 
2014-12-04 | E-GEOD-55184 | biostudies-arrayexpress
GenomicsSen1 and Rrm3 ensure permissive topological conditions for replication termination [ChIP-seq]
Sen1 and Rrm3 ensure permissive topological conditions for replication termination [ChIP-seq]
PRJNA887754 | ENA
GenomicsSen1 and Rrm3 ensure permissive topological conditions for replication termination [ChIP-chip]
Sen1 and Rrm3 ensure permissive topological conditions for replication termination [ChIP-chip]
PRJNA887726 | ENA
UnknownA Novel Rrm3 Function in Restricting DNA Replication via an Orc5-Binding Domain Is Genetically Separable from Rrm3 Function as an ATPase/Helicase in Facilitating Fork Progression.
Not available
S-EPMC5140057 | biostudies-literature
GenomicsSen1 and Rrm3 ensure permissive topological conditions for replication termination [ChIP-seq]
Replication forks terminate at TERs and telomeres. Forks that converge or encounter transcription generate topological stress. Combining genetic, genomic and imaging approaches we found that Rrm3hPif1 and Sen1hSenataxin helicases assist termination at TERs, Sen1 at telomeres. rrm3 and sen1 are synth...
ORGANISM(S): Saccharomyces cerevisiae 
2022-10-11 | GSE214925 | GEO
GenomicsSen1 and Rrm3 ensure permissive topological conditions for replication termination [ChIP-chip]
Replication forks terminate at TERs and telomeres. Forks that converge or encounter transcription generate topological stress. Combining genetic, genomic and imaging approaches we found that Rrm3hPif1 and Sen1hSenataxin helicases assist termination at TERs, Sen1 at telomeres. rrm3 and sen1 are synth...
ORGANISM(S): Saccharomyces cerevisiae 
2022-10-11 | GSE214908 | GEO
UnknownHuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs.
Not available
S-EPMC6344896 | biostudies-literature
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