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TranscriptomicsHuman lupus netting neutrophils induce endothelial damage, infiltrate tissues and expose immunostimulatory molecules
Our group has proposed that low-density granulocytes (LDGs) play an important role in lupus pathogenesis, as they can damage endothelial cells and synthesize increased levels of proinflammatory cytokines and type I interferons. LDGs have a heightened capacity to synthesize neutrophil extracellular t...
ORGANISM(S): Homo sapiens 
2011-06-22 | E-GEOD-26975 | biostudies-arrayexpress
GenomicsChIP-seq Identification of Weakly Conserved Heart Enhancers
Accurate control of tissue-specific gene expression plays a pivotal role in heart development. However, few cardiac transcriptional enhancers have thus far been identified. Extreme non-coding sequence conservation successfully predicts enhancers active in many tissues, but fails to identify substan...
ORGANISM(S): Mus musculus 
2010-08-22 | E-GEOD-22549 | biostudies-arrayexpress
GenomicsLarge-Scale Discovery of Enhancers from Human Heart Tissue
Development and function of the human heart depend on the dynamic control of tissue-specific gene expression by distant-acting transcriptional enhancers. While large numbers of heart enhancers have been identified using the mouse as a model system, many of these regulatory sequences are poorly cons...
ORGANISM(S): Mus musculus 
2011-12-04 | E-GEOD-32587 | biostudies-arrayexpress
GenomicsChIP-seq Accurately Predicts Tissue-Specific Activity of Enhancers
Determining the spatial and temporal activity patterns of enhancers remains a challenge in the functional annotation of the human genome. Here, we performed genome-wide mapping of tissue-specific in vivo binding sites for the enhancer-associated protein p300 and assessed in transgenic mice the util...
ORGANISM(S): Mus musculus 
2009-02-11 | E-GEOD-13845 | biostudies-arrayexpress
ProteomicsInflammatory signaling in human Tuberculosis granulomas is spatially organized
Granulomas are the pathological hallmark of tuberculosis (TB). However, their function and mechanisms of formation remain poorly understood. To understand the role of granulomas in TB, we analyzed the proteomes of granulomas from TB patients in an unbiased fashion. Using laser capture microdissecti...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080720 | MassIVE
GenomicsWhole Genome and Exon Capture Sequencing of Bladder Cancers

One primary bladder cancer and paired peripheral blood sample were subjected to whole genome sequencing on an Illumina HiSeq 2000 platform. This technology was utilized to investigate the genetic basis of a durable remission of metastatic bladder cancer in a patient treated with everolimus, a dru...

phs000535.v1.p1 | EGA
UnknownCancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis.
Not available
S-EPMC7002399 | biostudies-literature
UnknownPathway and network analysis of more than 2500 whole cancer genomes.
Not available
S-EPMC7002574 | biostudies-literature
UnknownCombined burden and functional impact tests for cancer driver discovery using DriverPower.
Not available
S-EPMC7002750 | biostudies-literature
UnknownIntegrative pathway enrichment analysis of multivariate omics data.
Not available
S-EPMC7002665 | biostudies-literature
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