Large-Scale Discovery of Enhancers from Human Heart Tissue

ABSTRACT: Development and function of the human heart depend on the dynamic control of tissue-specific gene expression by distant-acting transcriptional enhancers. While large numbers of heart enhancers have been identified using the mouse as a model system, many of these regulatory sequences are poorly conserved in the human genome. To generate an accurate genome-wide map of human heart enhancers, we used an epigenomic enhancer discovery approach and identified ~6,200 candidate enhancer sequences directly from fetal and adult human heart tissue. Consistent with their predicted function, these elements were markedly enriched near genes implicated in heart development, function and disease. To further validate their in vivo enhancer activity, we tested 65 of these human sequences in a transgenic

ORGANISM(S): Mus musculus

SUBMITTER: Matthew Blow 

PROVIDER: E-GEOD-32587 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress