Expanding the Catalog of Enhancer Marks In Vivo

ABSTRACT: While the majority of protein-coding genes in the human genome have been identified, the location of the regulatory sequences that control their expression in time and space remains poorly defined. The importance of identifying these elements is underscored by a growing number of studies (such as GWAS) supporting a relationship between variation in non-coding sequences and human disease. M-BM- emonstrated that ChIP-Seq with p300 directly on human or mouse tissues represents a powerful method to identify the location and tissue-specific activity pattern of enhancers in the genome.M-BM- a highly specific chromatin mark for the prediction of in vivo enhancers, it is not without limitations. M-BM- comparison of p300-bound regions with previously generated enhancer sets shows that the majority

ORGANISM(S): Mus musculus

SUBMITTER: Matthew Blow 

PROVIDER: E-GEOD-37151 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress