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TranscriptomicsLead exposure disrupts global DNA methylation in human embryonic stem cells and alters their neuronal differentiation
Exposure to lead (Pb) during childhood can result in learning disabilities and behavioral problems. Although described in animal models, whether Pb exposure also alters neuronal differentiation in the developing brains of exposed children is unknown. Here, we investigated the effects of physiologi...
ORGANISM(S): Homo sapiens 
2014-02-01 | E-GEOD-54596 | biostudies-arrayexpress
TranscriptomicsLead exposure induces changes in 5-hydroxymethylcytosine clusters in CpG islands in human embryonic stem cells and umbilical cord blood
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-06-08 | E-GEOD-69636 | biostudies-arrayexpress
TranscriptomicsLead Modulates trans- and cis-eQTLs in Drosophila melanogaster Heads
The goal was to study the effects of lead exposure on gene expression and identify the lead-responsive genes. After detecting 1,536 cis-eQTLs (FDR ≤ 10%) and 952 trans-eQTLs, we focused our analysis on Pb-sensitive “trans-eQTL hotspots”. 158 randomly selected Drosophila Synthetic Population Re...
ORGANISM(S): Drosophila melanogaster 
2016-06-10 | E-GEOD-83141 | biostudies-arrayexpress
TranscriptomicsMultigenerational epigenetic inheritance in humans: DNA methylation changes associated with maternal exposure to lead can be transmitted to the grandchildren
We report that the DNA methylation profile of a child’s neonatal whole blood can be significantly influenced by his or her mother’s neonatal blood lead levels (BLL). We recruited 35 mother-infant pairs in Detroit and measured the whole blood lead (Pb) levels and DNA methylation levels at over 450,00...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-GEOD-67444 | biostudies-arrayexpress
TranscriptomicsLead exposure induces changes in 5-hydroxymethylcytosine clusters in CpG islands in human embryonic stem cells and umbilical cord blood [ELEMENT]
Prenatal exposure to neurotoxicants such as lead (Pb) may cause stable changes in the DNA methylation (5mC) profile of the fetal genome. However few studies have examined its effect on the DNA de-methylation pathway, specifically the dynamic changes of the 5-hydroxymethylcytosine (5hmC) profile. The...
ORGANISM(S): Homo sapiens 
2015-06-08 | E-GEOD-69633 | biostudies-arrayexpress
TranscriptomicsLead exposure induces changes in 5-hydroxymethylcytosine clusters in CpG islands in human embryonic stem cells and umbilical cord blood [Pb_hESC]
Prenatal exposure to neurotoxicants such as lead (Pb) may cause stable changes in the DNA methylation (5mC) profile of the fetal genome. However few studies have examined its effect on the DNA de-methylation pathway, specifically the dynamic changes of the 5-hydroxymethylcytosine (5hmC) profile. The...
ORGANISM(S): Homo sapiens 
2015-06-08 | E-GEOD-69634 | biostudies-arrayexpress
UnknownThe Association of Prenatal Dietary Factors with Child Autism Diagnosis and Autism-Related Traits Using a Mixtures Approach: Results from the Environmental Influences on Child Health Outcomes Cohort.
Not available
S-EPMC12264552 | biostudies-literature
UnknownHost factors are associated with vaginal microbiome structure in pregnancy in the ECHO Cohort Consortium.
Not available
S-EPMC11116393 | biostudies-literature
UnknownCOVID-19 Pandemic Exposure and Toddler Behavioral Health in the ECHO Program.
Not available
S-EPMC12409581 | biostudies-literature
UnknownNeighborhood Food Access in Early Life and Trajectories of Child Body Mass Index and Obesity.
Not available
S-EPMC11406455 | biostudies-literature
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