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ProteomicsMTCH2 modulates CPT1 activity to regulate lipid metabolism of adipocytes
MTCH2 is a protein localized in the outer membrane of mitochondria. It belongs to the solute carrier 25 family, but its substrates or transporter function remains unknown. Previous research links MTCH2 to apoptosis induction, and Alzheimer’s disease, mitochondrial metabolism and dynamics, and MTCH2 ...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-20 | PXD054881 | Pride
Mouse Brown adipocytes Dia 
TranscriptomicsAmplification and overexpression of vinculin are associated with increased tumor cell proliferation and progression in advanced prostate cancer
We analyzed the 10q22 amplification in advanced prostate cancer and subjected the genes located in the common amplified region to an RNAi screen. We found vinculin as the most promising candidate gene and analyzed its protein expression on more than 400 prostate cancers by using the tissue micrarray...
ORGANISM(S): Homo sapiens 
2011-02-08 | E-GEOD-24216 | biostudies-arrayexpress
UnknownLatin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance.
Not available
S-EPMC6300600 | biostudies-literature
ProteomicsIdentification of human beta-2 microglobulin in bronchoalveolar lavage
The uploaded data is related to the identification of beta-2-microglobulin isolated from bronchoalveolar lavage. The sample was digested with trypsin and the proteolytic fragments were identified by MS/MS
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-12-15 | MSV000086602 | MassIVE
UnknownNatural selection shaped regional mtDNA variation in humans.
Not available
S-EPMC140917 | biostudies-literature
TranscriptomicsClonal relationship of relapsing diffuse large B-cell lymphoma
Recurrences of diffuse large B-cell lymphomas (DLBCL) result in significant morbidity and mortality, but their underlying genetic and biological mechanisms are unclear. Clonal relationship in DLBCL relapses so far is mostly addressed by the investigation of immunoglobulin (IG) rearrangements, theref...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-65720 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-sequencing resolves a CD4+ T cell fate bifurcation
Single-cell RNA sequencing (scRNA-seq) was used to study the various transcriptional states of individual CD4+ T cells during blood-stage Plasmodium chabaudi infection in mice. This is an experimental model of malaria in which CD4+ T cells are essential for controlling parasite numbers, and which is...
ORGANISM(S): Mus musculus 
2017-03-21 | E-MTAB-4388 | biostudies-arrayexpress
TranscriptomicsAdvancing a Clinically Relevant Perspective of the Clonal Nature of Cancer
We used DNA content-based flow cytometry to distinguish and isolate nuclei from clonal populations in primary tissues from three disparate cancers with variable clinical histories. We then developed a methodology to adapt flow cytometrically purified nuclei samples for use with whole genome technolo...
ORGANISM(S): Homo sapiens 
2011-07-04 | E-GEOD-21660 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of BrO, DMGO and GD2 CAR T cells
Diffuse midline glioma (DMG) is a lethal pediatric brain cancer with limited treatment options. We developed a human brainstem organoid model to study H3.3K27M-driven DMG, enabling formation of patient-like tumors with molecular heterogeneity. To characterize this model, we performed a time-course t...
ORGANISM(S): Homo sapiens 
2025-08-28 | E-MTAB-15147 | biostudies-arrayexpress
UnknownGenome-wide association study reveals genetic risk underlying Parkinson's disease.
Not available
S-EPMC2787725 | biostudies-literature
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