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TranscriptomicsFemale sex and oestrogen receptor β attenuate cardiac remodelling and apoptosis in pressure overload
Aims: We investigate sex differences and the role of oestrogen receptor beta (ERbeta) in a mouse model of pressure overload-induced myocardial hypertrophy. Methods and results: We performed transverse aortic constriction (TAC) or sham surgery in male and female wild-type (WT) and ER knockout (ERbet...
ORGANISM(S): Mus musculus 
2010-01-19 | E-GEOD-18224 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse HDAC2 knockout myocardium
We used microarrays to detail the global programme of gene expression underlying cardiac development by HDAC2 and identified distinct classes of up-regulated and down-regulated genes during this process. Experiment Overall Design: Embryonic heart ventricles were dissected at E17.5 for RNA extraction...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6770 | biostudies-arrayexpress
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