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UnknownThe effect of prophylactic anticoagulation on major bleeding events in hospitalized patients with chronic kidney disease and lower limb fractures: a phase 2, randomized, double-blind, controlled trial.
Not available
S-EPMC12648826 | biostudies-literature
UnknownAssociation of PTPN22 Haplotypes (-1123G>C/+1858C>T) with Rheumatoid Arthritis in Western Mexican Population.
Rheumatoid arthritis (RA) is an autoimmune disease characterized by the presence of antibodies against cyclic citrullinated peptide (anti-CCP), a consequence of the breakdown of immune tolerance. The lymphoid tyrosine phosphatase (Lyp) protein has significant effects on maintenance of peripheral imm...
S-EPMC5292183 | biostudies-literature
UnknownTranscription Factors Tec1 and Tec2 Play Key Roles in the Hyphal Growth and Virulence of Mucor lusitanicus Through Increased Mitochondrial Oxidative Metabolism.
Mucormycosis is a lethal and difficult-to-treat fungal infection caused by fungi of the order Mucorales. Mucor lusitanicus, a member of Mucorales, is commonly used as a model to understand disease pathogenesis. However, transcriptional control of hyphal growth and virulence in Mucorales is poorly un...
S-EPMC12126848 | biostudies-literature
UnknownA genome-wide association meta-analysis of all-cause and vascular dementia.

Introduction

Dementia is a multifactorial disease with Alzheimer's disease (AD) and vascular dementia (VaD) pathologies making the largest contributions. Yet, most genome-wide association studies (GWAS) focus on AD.

Methods

We conducted a GWAS of all-cause dementia (ACD) and examined ...
S-EPMC11497727 | biostudies-literature
UnknownOral versus intramuscular administration of vitamin B12 for the treatment of patients with vitamin B12 deficiency: a pragmatic, randomised, multicentre, non-inferiority clinical trial undertaken in the primary healthcare setting (Project OB12).

Background

The oral administration of vitamin B12 offers a potentially simpler and cheaper alternative to parenteral administration, but its effectiveness has not been definitively demonstrated. The following protocol was designed to compare the effectiveness of orally and intramuscularly ad...
S-EPMC3403849 | biostudies-literature
UnknownLinking genomic and proteomic signatures to brain amyloid burden: insights from GR@ACE/DEGESCO.
Alzheimer's disease (AD) is a complex disease with a strong genetic component, yet many genetic risk factors remain unknown. We combined genome-wide association studies (GWAS) on amyloid endophenotypes measured in cerebrospinal fluid (CSF) and positron emission tomography (PET) as surrogates of amyl...
S-EPMC11937198 | biostudies-literature
UnknownGastrointestinal symptoms and complications in patients hospitalized due to COVID-19, an international multicentre prospective cohort study (TIVURON project).

Background

Retrospective studies suggest that coronavirus disease (COVID-19) commonly involves gastrointestinal (GI) symptoms and complications. Our aim was to prospectively evaluate GI manifestations in patients hospitalized for COVID-19.

Methods

This international multicentre prospe...
S-EPMC9557114 | biostudies-literature
UnknownGastrointestinal symptoms and complications in patients hospitalized due to COVID-19, an international multicentre prospective cohort study (TIVURON project) Sintomas y complicaciones gastrointestinales en pacientes hospitalizados por COVID-19, estudio internacional, multicentrico, de cohorte, prospectivo (proyecto TIVURON)
Not available
S-EPMC10280146 | biostudies-literature
UnknownSex differences in the diagnosis latency of Parkinson's disease in Latin America.

Background

Age and sex are known risk factors for Parkinson's Disease (PD), but it remains controversial if there are sex differences in the diagnosis latency. The objective of this study was to examine these sex differences in Latin America.

Methods

The Latin American Research Consor...
S-EPMC12703624 | biostudies-literature
UnknownCIBERER: Spanish national network for research on rare diseases: A highly productive collaborative initiative.
CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedica...
S-EPMC9305285 | biostudies-literature
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