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ProteomicsThe pan-Sirtuin inhibitor MC2494 regulates mitochondrial function in a leukemia cell line
The involvement of sirtuins (SIRTs) in modulating metabolic and stress response pathways is attracting growing scientific interest. Some SIRT family members are located in mitochondria, dynamic organelles that perform several crucial functions essential for eukaryotic life. Mitochondrial dysfunction...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD017508 | Pride
Sirtuins Leukemia Human Mitochondria Orbitrap q-exactive 
ProteomicsPathological deficit of Cystatin B impairs synaptic plasticity in EPM1 human cerebral organoids
Cystatin B (CSTB) is a small protease inhibitor involved in cell proliferation and migration, and composition of extracellular matrix during brain development. Loss-of-function mutations in the gene encoding CSTB cause progressive myoclonic epilepsy 1 (EPM1). We previously demonstrated that CSTB is ...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD041125 | Pride
Epm1  cystatin b  synaptic plasticity 
ProteomicsCystatin B is essential for proliferation and interneuron migration in individuals with EPM1 epilepsy
Progressive myoclonus epilepsy (PME) of Unverricht-Lundborg-type (EPM1) is an autosomal recessive neurodegenerative disorder with the highest incidence of PME worldwide. Mutations in the gene encoding cystatin B (CSTB) are the primary genetic cause of EPM1. Here, we investigate the role of CSTB duri...
ORGANISM(S): Homo sapiens (Human) 
2020-05-13 | PXD018021 | Pride
Cystatin b  human cerebral organoids  progressive myoclonus epilepsy  mass spectrometry 
ProteomicsExploring the interaction between the SWI/SNF chromatin remodeling complex and the zinc finger factor CTCF
The transcription factor CCCTC-binding factor (CTCF) modulates pleiotropic functions mostly related to gene expression regulation. The role of CTCF in large scale genome organization is also well established. A unifying model to explain relationships between many CTCF-mediated activities involve dir...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022037 | Pride
Ctcf  swi/snf  brg1  mass spectrometry  protein‐protein interaction  brk  transcription factor  chromatin 
UnknownAspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC8598213 | biostudies-literature
UnknownTocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC8084355 | biostudies-literature
UnknownEmpagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC10957483 | biostudies-literature
UnknownPatterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry.
Not available
S-EPMC10518516 | biostudies-literature
UnknownCasirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC8830904 | biostudies-literature
UnknownBaricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis.
Not available
S-EPMC9333998 | biostudies-literature
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