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TranscriptomicsDefined hypoxic model timecourse of H37Rv and H37Rv:deltadosR
Background: A significant body of evidence accumulated over the last century suggests a link between hypoxic microenvironments within the infected host and the latent phase of tuberculosis. Studies to test this correlation have identified the M. tuberculosis initial hypoxic response, controlled by ...
ORGANISM(S): Mycobacterium tuberculosis 
2008-02-20 | E-GEOD-9331 | biostudies-arrayexpress
TranscriptomicsMycobacterium tuberculosis H37Rv transcriptional response to antibacterial agents
Bacteria commonly adapt to stresses by altering gene expression. To understand the response of M. tuberculosis (MTB) to various antibacterial agents, we performed transcriptomics on MTB bacilli exposed to several test compounds as well as known drugs (capreomycin, cycloserine, ethionamide, isoniazi...
ORGANISM(S): Mycobacterium tuberculosis 
2015-11-11 | E-GEOD-71200 | biostudies-arrayexpress
TranscriptomicsMapping and manipulating the M. tuberculosis transcriptome using a transcription factor overexpression-derived regulatory network
Expression data from transcription factor over expression experiments (Abstract from paper will be appended after publication) TFOE are matched to the ChIP-seq experiment done simultaneously.
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2014-07-04 | E-GEOD-59086 | biostudies-arrayexpress
TranscriptomicsmRNA degradation in Mycobacterium tuberculosis
This SuperSeries is composed of the following subset Series: GSE36341: mRNA degradation in Mycobacterium tuberculosis under aerobic conditions GSE36342: mRNA degradation in Mycobacterium smegmatis under aerobic conditions GSE36343: mRNA degradation in Mycobacterium tuberculosis during cold and hypox...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2012-03-08 | E-GEOD-36345 | biostudies-arrayexpress
TranscriptomicsmRNA degradation in Mycobacterium tuberculosis during cold and hypoxic stress
Transcription was arrested using 50 ug/ul of rifampin leaving RNA degradation as the sole vector responsible for mRNA abundance at 20C (cold) or in 0.2%O2 (hypoxia). mRNA half-lives were calculated from the decay of signal intensity from T0. Three replicates were sampled after 0, 1, 2, and 5 hours o...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2012-03-08 | E-GEOD-36343 | biostudies-arrayexpress
TranscriptomicsmRNA degradation in Mycobacterium tuberculosis with DosR ectopically induced
After induction of DosR from a tet regulated promoter (uninduced controls were treated with an equivalent ammount of the solvent, DMSO), transcription was arrested using 50 ug/ul of rifampin leaving RNA degradation as the sole vector responsible for mRNA abundance. mRNA half-lives were calculated fr...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2012-03-08 | E-GEOD-36344 | biostudies-arrayexpress
TranscriptomicsmRNA degradation in Mycobacterium tuberculosis under aerobic conditions
Transcription was arrested using 50 ug/ul of rifampin leaving RNA degradation as the sole vector responsible for mRNA abundance. mRNA half-lives were calculated from the decay of signal intensity from T0. Four replicates were sampled after 0, 5 10, 15, 20, and 30 minutes of mRNA decay for a total of...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2012-03-08 | E-GEOD-36341 | biostudies-arrayexpress
TranscriptomicsmRNA degradation in Mycobacterium smegmatis under aerobic conditions
Transcription was arrested using 50 ug/ul of rifampin leaving RNA degradation as the sole vector responsible for mRNA abundance. mRNA half-lives were calculated from the decay of signal intensity from T0. Three replicates were sampled before transcription arrest, and after 5 and 10 minutes of mRNA d...
ORGANISM(S): Mycobacterium smegmatis str. MC2 155 
2012-03-08 | E-GEOD-36342 | biostudies-arrayexpress
TranscriptomicsReconstruction of the Mycobacterium tuberculosis Regulatory Network and Deconstruction of the Hypoxic Response
Expression data from hypoxic time course and transcription factor over expression experiments. (Abstract from paper will be appended after publication) Hypoxic time course experiments were done with a minimum of 3 replicates. TFOE are matched to the ChIP-seq experiment done simultaneously. This subm...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2013-01-12 | E-GEOD-43466 | biostudies-arrayexpress
TranscriptomicsTowards understanding the biological function of the unusual chaperonin GroEL1 of Mycobacterium tuberculosis
Expression data from wild type (H37Rv) and GroEL1(H37RvΔgroEL1::Hyg) mutant strains under a range of environmental stresses The 60 kDa heat shock proteins, also known as GroELs are components of the essential protein folding machinery of the cell, but are also dominant antigens in many infectious di...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2015-05-14 | E-GEOD-68856 | biostudies-arrayexpress
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